Highly Stereodivergent Synthesis of Chiral C4-Ester-Quaternary Pyrrolidines: A Strategy for the Total Synthesis of Spirotryprostatin A.
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DOI: 10.1021/acs.orglett.3c00904
Abstract: In this work, we disclose two sets of highly diastereo- and enantioselective [3 + 2] cycloadditions of iminoesters with various α-substituted acrylates, especially for sterically hindered and weakly activated α-aryl or alkyl-substituted acrylates and alkenal,… read more here.
Keywords: ester quaternary; synthesis; synthesis chiral; chiral ester ... See more keywords