Comparative Effectiveness of Cholesteryl Ester Transfer Protein (CETP) Inhibitors on Lipid Profiles in Adults With Hyperlipidemia: A Comprehensive Systematic Review and Frequentist Network Meta‐Analysis of Randomized Controlled Trials
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DOI: 10.1002/clc.70204
Abstract: Hyperlipidemia, a key risk factor for cardiovascular disease, is characterized by elevated low‐density lipoprotein cholesterol (LDL‐C), triglycerides, and reduced high‐density lipoprotein cholesterol (HDL‐C). Cholesteryl ester transfer protein (CETP) inhibitors, such as anacetrapib, obicetrapib, evacetrapib, dalcetrapib,… read more here.
Keywords: cholesteryl ester; ester transfer; transfer protein; protein cetp ... See more keywords
Do Cholesteryl Ester Transfer Protein Inhibitors Have a Role in the Treatment of Cardiovascular Disease?
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Cardiovascular Drugs"
DOI: 10.1007/s40256-018-00323-3
Abstract: Cholesteryl ester transfer protein (CETP) plays an important role in lipid metabolism and has presented an attractive target for drug development, primarily resting on the hope that CETP inhibition would reduce cardiovascular events through its… read more here.
Keywords: transfer protein; cholesteryl ester; ester transfer;
The role of cholesteryl ester transfer protein expression on endothelial cells: oxidative stress and vascular dysfunction
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.04.312
Abstract: High-density lipoprotein cholesterol (HDL-C) levels are inversely correlated with development of atherosclerotic coronary heart disease and studies demonstrate that cholesteryl ester transfer protein (CETP) deficiency is associated with markedly increased HDL levels. HDL may exert… read more here.
Keywords: transfer protein; dysfunction; cholesteryl ester; role ... See more keywords
Bound Phospholipids Assist Cholesteryl Ester Transfer in the Cholesteryl Ester Transfer Protein
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DOI: 10.1021/acs.jcim.2c01340
Abstract: Cholesteryl ester transfer protein (CETP) is a plasma glycoprotein that assists the transfer of cholesteryl esters (CEs) from antiatherogenic high-density lipoproteins (HDLs) to proatherogenic low-density lipoproteins (LDLs), initiating cholesterol plaques in the arteries. Consequently, inhibiting… read more here.
Keywords: transfer; cholesteryl ester; pls; ester transfer ... See more keywords
[1,3]-Carboxylic Ester Transfer Reactions: Synthesis of Structurally Challenging Bisindolylmethyl Chromone Hybrids.
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DOI: 10.1021/acs.orglett.5c04120
Abstract: Herein, we report the first example of a [1,3]-carboxylic ester transfer reaction of chromone-based α-keto esters with indoles for the efficient synthesis of densely functionalized bisindolylmethyl chromone hybrids. These structurally challenging products, including two bisindolylmethane… read more here.
Keywords: structurally challenging; carboxylic ester; chromone hybrids; ester transfer ... See more keywords
Ester Transfer Reaction of Aromatic Esters with Haloarenes and Arenols by a Nickel Catalyst
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DOI: 10.1021/acscatal.0c00291
Abstract: A catalytic ester transfer reaction of aromatic esters with aryl halides/arenols was developed. The present reaction can transfer an ester functional group from certain aromatic esters to haloarene... read more here.
Keywords: transfer reaction; aromatic esters; transfer; reaction aromatic ... See more keywords
Alterations of lipid metabolism, blood pressure and fatty liver in spontaneously hypertensive rats transgenic for human cholesteryl ester transfer protein
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DOI: 10.1038/s41440-020-0401-9
Abstract: Cholesteryl ester transfer protein (CETP) mediates a step in reverse cholesterol transport, which channels cholesterol from peripheral tissues back to the liver. Mice and rats are CETP-deficient species, which assumedly contribute to rodent atherosclerosis resistance.… read more here.
Keywords: transfer protein; spontaneously hypertensive; hypertensive rats; cholesteryl ester ... See more keywords
How cholesteryl ester transfer protein can also be a potential triglyceride transporter
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DOI: 10.1038/s41598-017-05449-z
Abstract: CETP transfers cholesteryl esters (CEs) and triglycerides (TGs) between different lipoproteins and came in limelight as a drug-target against CVD. In the search for detailed mechanism of lipid transfer through CETP, enormous effort is devoted… read more here.
Keywords: transfer protein; protein also; cholesteryl ester; transfer ... See more keywords
The Cholesteryl Ester Transfer Protein Inhibitor, des-Fluoro-Anacetrapib, Prevents Vein Bypass-induced Neointimal Hyperplasia in New Zealand White Rabbits
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DOI: 10.1038/s41598-019-52510-0
Abstract: Coronary artery bypass grafting is among the most commonly performed of all cardiovascular surgical procedures. However, graft failure due to stenosis reduces the long-term benefit of the intervention. This study asks if elevating plasma high… read more here.
Keywords: des fluoro; bypass grafting; cholesteryl ester; fluoro anacetrapib ... See more keywords
Reliable structural information for rational design of benzoxazole type potential cholesteryl ester transfer protein (CETP) inhibitors through multiple validated modeling techniques
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DOI: 10.1080/07391102.2018.1552895
Abstract: Abstract The drug design and discovery of lipid modulators is very demanding as no new molecule has entered into the market in the last 35 years. Cholesteryl ester transfer protein (CETP) is a promising target… read more here.
Keywords: transfer protein; benzoxazole; cholesteryl ester; cetp ... See more keywords
Design and development of novel therapeutics for coronary heart disease treatment based on cholesteryl ester transfer protein inhibition – in silico approach
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2019.1630319
Abstract: Abstract Cholesteryl ester transfer protein (CETP) belongs to the group of enzymes which inhibition have the application in the treatment of cardiovascular diseases. This study presents QSAR modeling for a set of compounds acting as… read more here.
Keywords: transfer protein; cholesteryl ester; ester transfer;