Engineering a bacterial platform for total biosynthesis of caffeic acid derived phenethyl esters and amides.
Sign Up to like & getrecommendations! Published in 2017 at "Metabolic engineering"
DOI: 10.1016/j.ymben.2017.09.011
Abstract: Caffeic acid has been widely recognized as a versatile pharmacophore for synthesis of new chemical entities, among which caffeic acid derived phenethyl esters and amides are the most extensively-investigated bioactive compounds with potential therapeutical applications.… read more here.
Keywords: caffeic acid; acid derived; derived phenethyl; phenethyl esters ... See more keywords
Nickel-Catalyzed Asymmetric Hydrogenation of γ-Keto Acids, Esters, and Amides to Chiral γ-Lactones and γ-Hydroxy Acid Derivatives.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00826
Abstract: A highly efficient asymmetric hydrogenation of a series of γ-keto acid derivatives, including γ-keto acids, esters, and amides, using a Ni-(R,R)-QuinoxP* complex as the catalyst has been developed to afford chiral γ-hydroxy acid derivatives with… read more here.
Keywords: esters amides; asymmetric hydrogenation; acids esters; keto ... See more keywords
Manganese-Catalyzed α-Alkylation of Ketones, Esters, and Amides Using Alcohols
Sign Up to like & getrecommendations! Published in 2018 at "ACS Catalysis"
DOI: 10.1021/acscatal.8b03720
Abstract: Herein we report the manganese-catalyzed C–C bond-forming reactions via α-alkylation of ketones, amides, and esters, using primary alcohols. β-Alkylation of secondary alcohols by primary alcohols to obtain α-alkylated ketones is also reported. The reactions are… read more here.
Keywords: manganese catalyzed; catalyzed alkylation; esters amides; alkylation ... See more keywords
Catalytic enantioselective synthesis of α-aryl α-hydrazino esters and amides.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc02478c
Abstract: Catalysts generated by combinations of Pd(TFA)2 and pyridine-hydrazone ligands have allowed the asymmetric 1,2-addition of aryl boronic acids to N-carbamoyl (Cbz and Fmoc) protected glyoxylate-derived hydrazones, yielding α-aryl α-hydrazino esters/amides in high enantioselectivities. Subsequent removal… read more here.
Keywords: catalytic enantioselective; aryl hydrazino; hydrazino esters; esters amides ... See more keywords
Insights into self-degradation of cysteine esters and amides under physiological conditions yield new cleavable chemistry.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc00684k
Abstract: An unprecedented H2S release from cysteine esters and amides (CysO/NHR) under physiological conditions was discovered and the plausible mechanism was proposed. Alkylation of the amino moiety of cysteine esters enables the H2S release to be… read more here.
Keywords: insights self; esters amides; chemistry; cysteine esters ... See more keywords
Yttrium-Catalyzed Regioselective Aminolysis of 2,3-Epoxy Esters and Amides
Sign Up to like & getrecommendations! Published in 2023 at "Synlett"
DOI: 10.1055/a-2077-5084
Abstract: Herein a yttrium-catalyzed regioselective ring opening reaction of 2,3-epoxy esters and amides with amines as nucleophiles is pre-sented. This method features high regiocontrol, enantiospecific SN2 reaction pathway, broad substrate scope and mild reaction condi-tions, furnishing… read more here.
Keywords: epoxy esters; catalyzed regioselective; yttrium catalyzed; esters amides ... See more keywords