Enantioselective Synthesis of α-Allyl Amino Esters via Hydrogen-Bond Donor Catalysis.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b05556
Abstract: We report a chiral-squaramide-catalyzed enantio- and diastereoselec-tive synthesis of α-allyl amino esters. The optimized protocol provides access to N-carbamoyl-protected amino esters via nucleophilic allyla-tion of readily accessible α-chloro glycinates. A variety of useful α-allyl amino… read more here.
Keywords: amino esters; esters via; allyl amino; synthesis allyl ... See more keywords
Cu(I)-Catalyzed stereoselective synthesis of trisubstituted Z-enol esters via interrupting the 1,3-O-transposition reaction
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DOI: 10.1039/c8qo00664d
Abstract: An efficient Cu(I)-catalyzed stereoselective synthesis of trisubstituted Z-enol esters via interrupting the 1,3-O-transposition process is reported. This method provided a convenient approach to highly functionalized Z-enol esters with mild reaction conditions and wide substrate scope. read more here.
Keywords: trisubstituted enol; esters via; stereoselective synthesis; catalyzed stereoselective ... See more keywords
Synthesis of α-Amino Esters via α-Nitro or α-Oxime Esters: A Review
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DOI: 10.1055/s-0036-1589506
Abstract: This review is an in-depth survey of the reported synthetic approaches for the preparation of racemic α-amino esters via the reduction of α-nitro or α-oxime ester intermediates. Accordingly, it describes the many pathways that have… read more here.
Keywords: oxime esters; amino esters; esters via; synthesis amino ... See more keywords
Isoniazid Linked to Sulfonate Esters via Hydrazone Functionality: Design, Synthesis, and Evaluation of Antitubercular Activity
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DOI: 10.3390/ph15101301
Abstract: Isoniazid (INH) is one of the key molecules employed in the treatment of tuberculosis (TB), the most deadly infectious disease worldwide. However, the efficacy of this cornerstone drug has seriously decreased due to emerging INH-resistant… read more here.
Keywords: sih1 sih13; sulfonate esters; esters via; inh ... See more keywords