Defining estimands in clinical trials: A unified procedure
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DOI: 10.1002/sim.9702
Abstract: The ICH E9 (R1) addendum proposes five strategies to define estimands by addressing intercurrent events. However, mathematical forms of these targeted quantities are lacking, which might lead to discordance between statisticians who estimate these quantities… read more here.
Keywords: trials unified; unified procedure; estimands clinical; clinical trials ... See more keywords
Treatment estimands in clinical trials of patients hospitalised for COVID-19: ensuring trials ask the right questions
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DOI: 10.1186/s12916-020-01737-0
Abstract: When designing a clinical trial, explicitly defining the treatment estimands of interest ( that which is to be estimated ) can help to clarify trial objectives and ensure the questions being addressed by the… read more here.
Keywords: estimands clinical; patients hospitalised; treatment; clinical trials ... See more keywords