Stereoselective synthesis of the four 16-hydroxymethyl-3-methoxy- and 16-hydroxymethyl-3-benzyloxy-13α-estra-1,3,5(10)-trien-17-ol isomers and their antiproliferative activities
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DOI: 10.1016/j.steroids.2018.02.008
Abstract: Graphical abstract Figure. No caption available. HighlightsStereoselective synthesis of diastereomeric diols.Straightforward synthetic route from trans‐ to cis‐diols.Substantial antiproliferative action against HeLa. &NA; The reduction of 16‐hydroxymethylene‐3‐methoxy‐13&agr;‐estra‐1,3,5(10)‐trien‐17‐one (14) and 16‐hydroxymethylene‐3‐benzyloxy‐13&agr;‐estra‐1,3,5(10)‐trien‐17‐one (16) yielded a mixture of two… read more here.
Keywords: benzyloxy; hydroxymethyl; estra trien; antiproliferative activities ... See more keywords