A CRH receptor type 1 agonist increases GABA transmission to GnRH neurons in a circulating-estradiol-dependent manner.
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DOI: 10.1210/endocr/bqaa140
Abstract: GnRH neurons are central regulators of reproduction and respond to factors affecting fertility, such as stress. Corticotropin-releasing hormone (CRH) is released during stress response. In brain slices from unstressed controls, CRH has opposite, estradiol-dependent, effects… read more here.
Keywords: crh receptor; gnrh neurons; circulating estradiol; estradiol dependent ... See more keywords