Estradiol up-regulates L-type Ca2+ channels via membrane-bound estrogen receptor/phosphoinositide-3-kinase/Akt/cAMP response element-binding protein signaling pathway.
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DOI: 10.1016/j.hrthm.2018.01.019
Abstract: BACKGROUND In long QT syndrome type 2, women are more prone than men to the lethal arrhythmia torsades de pointes. We previously reported that 17β-estradiol (E2) up-regulates L-type Ca2+ channels and current (ICa,L) (∼30%) in… read more here.
Keywords: akt; regulates type; kinase; ca2 ... See more keywords