2‐Difluoromethoxy‐Substituted Estratriene Sulfamates: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Steroid Sulfatase Inhibition
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200408
Abstract: 2‐Difluoromethoxyestratriene derivatives were designed to improve potency and in vivo stability of the drug candidate 2‐methoxyestradiol (2ME2). Compound evaluation in vitro against the proliferation of MCF‐7 and MDA MB‐231 breast cancer cells, as inhibitors of tubulin polymerisation… read more here.
Keywords: difluoromethoxy substituted; steroid sulfatase; inhibition; substituted estratriene ... See more keywords