Luteolin-7-methylether from Leonurus japonicus inhibits estrogen biosynthesis in human ovarian granulosa cells by suppression of aromatase (CYP19).
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173154
Abstract: Leonurus japonicus (motherwort) has been widely used to treat gynecological disorders, in which estrogen is often dysregulated, for a long time in China and other Asian countries. However, the chemical constituents and mechanisms underlying the… read more here.
Keywords: biosynthesis; estrogen biosynthesis; aromatase; xly29 ... See more keywords
Estrogen Biosynthesis and Signal Transduction in Ovarian Disease
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DOI: 10.3389/fendo.2022.827032
Abstract: Estrogen mainly binds to estrogen receptors (ERs) to regulate menstrual cycles and reproduction. The expression of ERalpha (ERα), ERbeta (ERβ), and G-protein-coupled estrogen receptor (GPER) mRNA could be detected in ovary, suggesting that they play… read more here.
Keywords: signal transduction; estrogen biosynthesis; estrogen; ovarian disease ... See more keywords
Assessment of Five Pesticides as Endocrine-Disrupting Chemicals: Effects on Estrogen Receptors and Aromatase
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DOI: 10.3390/ijerph19041959
Abstract: Pesticides are widely applied all over the world, and pesticide exposure can induce different biological effects posing a possible threat to human health. Due to their effects on the endocrine system, some pesticides are classified… read more here.
Keywords: five pesticides; estrogen biosynthesis; estrogen signaling; pesticides estrogen ... See more keywords