Treatment of estrogen-dependent diseases: Design, synthesis and profiling of a selective 17β-HSD1 inhibitor with sub-nanomolar IC50 for a proof-of-principle study.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.11.004
Abstract: Current endocrine therapeutics for the estrogen-dependent disease endometriosis often lead to considerable side-effects as they act by reducing estrogen action systemically. A more recent approach takes advantage of the fact that the weak estrogen estrone… read more here.
Keywords: estrogen dependent; hsd1; estrogen; nanomolar ic50 ... See more keywords
AIB1 sequestration by androgen receptor inhibits estrogen-dependent cyclin D1 expression in breast cancer cells
Sign Up to like & getrecommendations! Published in 2019 at "BMC Cancer"
DOI: 10.1186/s12885-019-6262-4
Abstract: BackgroundAndrogens, through their own receptor, play a protective role on breast tumor development and progression and counterbalance estrogen-dependent growth stimuli which are intimately linked to breast carcinogenesis.MethodsCell counting by trypan blu exclusion was used to… read more here.
Keywords: estrogen dependent; androgen; breast; cyclin ... See more keywords
Predictor for supraphysiologic serum estradiol elevation on hCG triggering day of controlled ovarian stimulation using letrozole and gonadotropins in women with estrogen-dependent cancers
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DOI: 10.1371/journal.pone.0240870
Abstract: The objective of this study was to evaluate predicting factors for supraphysiologic serum estradiol elevation during controlled ovarian stimulation (COS) with administration of letrozole and gonadotropins in patients with estrogen-dependent cancer. Use of aromatase inhibitors… read more here.
Keywords: estrogen dependent; estradiol; stimulation; day ... See more keywords
MiR-196a-5p facilitates progression of estrogen-dependent endometrial cancer by regulating FOXO1.
Sign Up to like & getrecommendations! Published in 2022 at "Histology and histopathology"
DOI: 10.14670/hh-18-572
Abstract: BACKGROUND AND PURPOSE Estrogen-dependent endometrial cancer mainly occurs in younger pre-menopausal and post-menopausal women and threatens their health. Recently, microRNAs (miRNAs) have been considered as novel targets in endometrial cancer treatment. Therefore, we aimed to… read more here.
Keywords: endometrial cancer; dependent endometrial; mir 196a; estrogen dependent ... See more keywords
Estrogen-Dependent Changes in Dura Mater Microvasculature Add New Insights to the Pathogenesis of Headache
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DOI: 10.3389/fneur.2017.00549
Abstract: The pathogenesis of headaches is a matter of ongoing discussion of two major theories describing it either as a vascular phenomenon resulting from vasodilation or primarily as a neurogenic process accompanied by secondary vasodilation associated… read more here.
Keywords: estrogen dependent; pathogenesis; dura mater; new insights ... See more keywords