Estrogen-independent Myc overexpression confers endocrine therapy resistance on breast cancer cells expressing ERαY537S and ERαD538G mutations.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.10.041
Abstract: Approximately 30% of metastatic breast cancers harbor estrogen receptor α (ERα) mutations associated with resistance to endocrine therapy and reduced survival. Consistent with their constitutive proliferation, T47D and MCF7 cells in which wild-type ERα is… read more here.
Keywords: endocrine therapy; breast; mutant cells; y537s d538g ... See more keywords
Estrogen-independent regulation of myocardial autophagy by the G protein-coupled estrogen receptor 1
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733765
Abstract: Study Objective and Hypothesis: Macroautophagy is a process that degrades unwanted cellular components (cargo) to maintain tissue homeostasis. It operates basally but is upregulated under stressful conditions such as nutrient deprivation. Myocardial autophagy is cardioprotective,… read more here.
Keywords: physiology; estrogen independent; myocardial autophagy; gper ... See more keywords