The formation of estrogen-like tamoxifen metabolites and their influence on enzyme activity and gene expression of ADME genes
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DOI: 10.1007/s00204-017-2147-y
Abstract: Tamoxifen, a standard therapy for breast cancer, is metabolized to compounds with anti-estrogenic as well as estrogen-like action at the estrogen receptor. Little is known about the formation of estrogen-like metabolites and their biological impact.… read more here.
Keywords: tamoxifen bisphenol; tamoxifen; activity; estrogen like ... See more keywords
Estradiol and Estrogen-like Alternative Therapies in Use: The Importance of the Selective and Non-Classical Actions
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DOI: 10.3390/biomedicines10040861
Abstract: Estrogen is one of the most important female sex hormones, and is indispensable for reproduction. However, its role is much wider. Among others, due to its neuroprotective effects, estrogen protects the brain against dementia and… read more here.
Keywords: estrogen; selective non; non classical; like alternative ... See more keywords
Emerging Estrogenic Pollutants in the Aquatic Environment and Breast Cancer
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DOI: 10.3390/genes8090229
Abstract: The number and amount of man-made chemicals present in the aquatic environment has increased considerably over the past 50 years. Among these contaminants, endocrine-disrupting chemicals (EDCs) represent a significant proportion. This family of compounds interferes… read more here.
Keywords: estrogen like; environment; breast; breast cancer ... See more keywords
The Prevalence of Dietary Supplements That Claim Estrogen-like Effects in Japanese Women
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DOI: 10.3390/nu14214509
Abstract: Recently, adverse events, such as irregular vaginal bleeding and menstrual disorders, associated with the use of dietary supplements containing Pueraria mirifica, have been reported in Japan. P. mirifica contains phytoestrogens, such as deoxymiroestrol and miroestrol.… read more here.
Keywords: estrogen; claim estrogen; dietary supplements; supplements claim ... See more keywords