The formation of estrogen-like tamoxifen metabolites and their influence on enzyme activity and gene expression of ADME genes
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Toxicology"
DOI: 10.1007/s00204-017-2147-y
Abstract: Tamoxifen, a standard therapy for breast cancer, is metabolized to compounds with anti-estrogenic as well as estrogen-like action at the estrogen receptor. Little is known about the formation of estrogen-like metabolites and their biological impact.… read more here.
Keywords: tamoxifen bisphenol; tamoxifen; activity; estrogen like ... See more keywords
Psoralen and Isopsoralen, Two Estrogen-Like Natural Products from Psoraleae Fructus, Induced Cholestasis via Activation of ERK1/2.
Sign Up to like & getrecommendations! Published in 2024 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.4c00054
Abstract: With the increasing use of oral contraceptives and estrogen replacement therapy, the incidence of estrogen-induced cholestasis (EC) has tended to rise. Psoralen (P) and isopsoralen (IP) are the major bioactive components in Psoraleae Fructus, and… read more here.
Keywords: psoralen isopsoralen; estrogen like; psoraleae fructus; induced cholestasis ... See more keywords
Estradiol and Estrogen-like Alternative Therapies in Use: The Importance of the Selective and Non-Classical Actions
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10040861
Abstract: Estrogen is one of the most important female sex hormones, and is indispensable for reproduction. However, its role is much wider. Among others, due to its neuroprotective effects, estrogen protects the brain against dementia and… read more here.
Keywords: estrogen; selective non; non classical; like alternative ... See more keywords
Estrogen-like Activity of Scrophularia buergeriana Root Extracts in MCF-7 Cells
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DOI: 10.3390/biomedicines13092151
Abstract: Background/Objectives: Estrogen deficiency-related menopause is associated with various physical and psychological symptoms. Although hormone replacement therapy (HRT) effectively alleviates these symptoms, its long-term use is associated with several side effects such as an increased risk… read more here.
Keywords: like activity; estrogen like; cell; scrophularia buergeriana ... See more keywords
Emerging Estrogenic Pollutants in the Aquatic Environment and Breast Cancer
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DOI: 10.3390/genes8090229
Abstract: The number and amount of man-made chemicals present in the aquatic environment has increased considerably over the past 50 years. Among these contaminants, endocrine-disrupting chemicals (EDCs) represent a significant proportion. This family of compounds interferes… read more here.
Keywords: estrogen like; environment; breast; breast cancer ... See more keywords
Korean Black Goat Extract Exerts Estrogen-like Osteoprotective Effects by Stimulating Osteoblast Differentiation in MC3T3-E1 Cells and Suppressing Osteoclastogenesis in RAW 264.7 Cells
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms25137247
Abstract: Postmenopausal osteoporosis, characterized by an imbalance between osteoclast-mediated bone resorption and osteoblast-driven bone formation, presents substantial health implications. In this study, we investigated the role of black goat extract (BGE), derived from a domesticated native… read more here.
Keywords: goat; goat extract; estrogen like; black goat ... See more keywords
The Prevalence of Dietary Supplements That Claim Estrogen-like Effects in Japanese Women
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DOI: 10.3390/nu14214509
Abstract: Recently, adverse events, such as irregular vaginal bleeding and menstrual disorders, associated with the use of dietary supplements containing Pueraria mirifica, have been reported in Japan. P. mirifica contains phytoestrogens, such as deoxymiroestrol and miroestrol.… read more here.
Keywords: estrogen; claim estrogen; dietary supplements; supplements claim ... See more keywords