Frontline Science: Estrogen‐related receptor γ increases poly(I:C)‐mediated type I IFN expression in mouse macrophages
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.2hi1219-762r
Abstract: Although type I IFNs (IFN‐I) are important for the innate and adaptive immune responses to suppress viral replication, prolonged IFN‐I signaling in macrophages suppresses the immune response. Nuclear receptor estrogen‐related receptor γ (ERRγ) regulates the… read more here.
Keywords: expression; related receptor; poly mediated; estrogen related ... See more keywords
Indazole-based ligands for estrogen-related receptor α as potential anti-diabetic agents.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.07.015
Abstract: Estrogen-related receptor α (ERRα) is an orphan nuclear receptor that has been functionally implicated in the regulation of energy homeostasis. Herein is described the development of indazole-based N-alkylthiazolidenediones, which function in biochemical assays as selective… read more here.
Keywords: indazole based; based ligands; ligands estrogen; receptor ... See more keywords
Resveratrol attenuates high fat diet‐induced mouse cardiomyopathy through upregulation of estrogen related receptor‐&agr;
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.10.018
Abstract: ABSTRACT Resveratrol reportedly promotes the improvement of cardiac dysfunction and other cardiovascular diseases. Studies demonstrate resveratrol exhibits a set of benefits, including anti‐oxidative property, anti‐apoptosis and anti‐inflammation. However, the molecular mediators of resveratrol‐induced cardiac benefits… read more here.
Keywords: resveratrol; agr; err agr; related receptor ... See more keywords
Structure-Dependent Activity of Polybrominated Diphenyl Ethers and Their Hydroxylated Metabolites on Estrogen Related Receptor γ: in Vitro and in Silico Study.
Sign Up to like & getrecommendations! Published in 2018 at "Environmental science & technology"
DOI: 10.1021/acs.est.8b02509
Abstract: Estrogen-related receptor γ (ERRγ) is an orphan nuclear receptor having functional cross-talk with classical estrogen receptors. Here, we investigated whether ERRγ is a potential target of polybrominated diphenyl ethers (PBDEs) and their hydroxylated metabolites (OH-PBDEs).… read more here.
Keywords: pbdes pbdes; activity; binding; related receptor ... See more keywords
Influence of estrogen-related receptor γ (ESRRG) rs1890552 A > G polymorphism on changes in fasting glucose and arterial stiffness
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DOI: 10.1038/s41598-017-10192-6
Abstract: To determine the effects of the estrogen-related receptor γ (ESRRG) rs1890552 A > G polymorphism on dietary advice-mediated changes in fasting glucose and arterial stiffness, 374 subjects with normal fasting glucose (NFG; control group, no treatment) and… read more here.
Keywords: esrrg rs1890552; changes fasting; rs1890552 polymorphism; fasting glucose ... See more keywords
Estrogen-related Receptor Signaling in Skeletal Muscle Fitness
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Sports Medicine"
DOI: 10.1055/a-2035-8192
Abstract: Abstract Skeletal muscle is a highly plastic tissue that can alter its metabolic and contractile features, as well as regenerative potential in response to exercise and other conditions. Multiple signaling factors including metabolites, kinases, receptors,… read more here.
Keywords: estrogen related; muscle; receptor signaling; related receptor ... See more keywords
Ligand pathways in estrogen-related receptors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2022.2027818
Abstract: Abstract The three subtypes of estrogen-related receptors ERRα, ERRβ, and ERRγ are nuclear receptors mediating metabolic processes in various tissues such as the skeletal muscle, fat tissue, bone, and liver. Although the knowledge on their… read more here.
Keywords: pathways estrogen; estrogen related; receptors ligand; ligand pathways ... See more keywords
ESRRA (estrogen-related receptor α) is a key coordinator of transcriptional and post-translational activation of autophagy to promote innate host defense
Sign Up to like & getrecommendations! Published in 2018 at "Autophagy"
DOI: 10.1080/15548627.2017.1339001
Abstract: ABSTRACT The orphan nuclear receptor ESRRA (estrogen-related receptor α) is a key regulator of energy homeostasis and mitochondrial function. Macroautophagy/autophagy, an intracellular degradation process, is a critical innate effector against intracellular microbes. Here, we demonstrate… read more here.
Keywords: esrra estrogen; activation; receptor; related receptor ... See more keywords
ESRRA (estrogen related receptor alpha) is a critical regulator of intestinal homeostasis through activation of autophagic flux via gut microbiota
Sign Up to like & getrecommendations! Published in 2020 at "Autophagy"
DOI: 10.1080/15548627.2020.1847460
Abstract: ABSTRACT The orphan nuclear receptor ESRRA (estrogen related receptor alpha) is critical in mitochondrial biogenesis and macroautophagy/autophagy function; however, the roles of ESRRA in intestinal function remain uncharacterized. Herein we identified that ESRRA acts as… read more here.
Keywords: esrra; gut microbiota; receptor; related receptor ... See more keywords
Nuclear receptor estrogen-related receptor gamma suppresses colorectal cancer aggressiveness by regulating Wnt/β-catenin signalling.
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DOI: 10.1093/carcin/bgac054
Abstract: Colorectal cancer is the predominant cause of cancer-related death worldwide, because of lack of effective therapeutic targets. Estrogen-related receptor gamma (ESRRG), which belongs to the family of nuclear receptors, functions as an important element regulating… read more here.
Keywords: estrogen related; colorectal cancer; related receptor; receptor gamma ... See more keywords
Loss of Estrogen-Related Receptor Alpha Facilitates Angiogenesis in Endothelial Cells
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Biology"
DOI: 10.1128/mcb.00411-18
Abstract: Estrogen-related receptors (ERRs) have emerged as major metabolic regulators in various tissues. However, their expression and function in the vasculature remains unknown. ABSTRACT Estrogen-related receptors (ERRs) have emerged as major metabolic regulators in various tissues.… read more here.
Keywords: err; estrogen; estrogen related; loss estrogen ... See more keywords