Estrogen receptor variant ER‐α36 facilitates estrogen signaling via EGFR in glioblastoma
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11877
Abstract: Glioblastoma (GBM) is a deadly and common primary brain tumor. Poor prognosis is linked to high proliferation and cell heterogeneity. Sex differences may play a role in patient outcome. Previous studies showed that ER‐α36, a… read more here.
Keywords: signaling via; estrogen receptor; estrogen; gbm ... See more keywords
Membrane-initiated estrogen signaling via Gq-coupled GPCR in the central nervous system
Sign Up to like & getrecommendations! Published in 2019 at "Steroids"
DOI: 10.1016/j.steroids.2018.01.010
Abstract: &NA; The last few decades have revealed increasing complexity and depth to our knowledge of receptor‐mediated estrogen signaling. Nuclear estrogen receptors (ERs) ER&agr; and ER&bgr; remain the fundamental dogma, but recent research targeting membrane‐bound ERs… read more here.
Keywords: nervous system; central nervous; membrane; estrogen signaling ... See more keywords
Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-018-08046-4
Abstract: Central estrogen signaling coordinates energy expenditure, reproduction, and in concert with peripheral estrogen impacts skeletal homeostasis in females. Here, we ablate estrogen receptor alpha (ERα) in the medial basal hypothalamus and find a robust bone… read more here.
Keywords: kiss1 neurons; sex dependent; estrogen; bone ... See more keywords
Asperosaponin VI induces osteogenic differentiation of human umbilical cord mesenchymal stem cells via the estrogen signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000032344
Abstract: Background: Asperosaponin VI (ASA VI) is an active ingredient found in the traditional Chinese herb Radix Dipsaci, which is used to treat fractures. ASA VI combined with osteogenic medium can induce osteogenic differentiation of rat-derived… read more here.
Keywords: estrogen; signaling pathway; osteogenic differentiation; differentiation ... See more keywords
Targeting estrogen signaling in the radiation-induced neurodegeneration: possible role of phytoestrogens.
Sign Up to like & getrecommendations! Published in 2022 at "Current neuropharmacology"
DOI: 10.2174/1570159x20666220310115004
Abstract: Radiation for medical use is a well-established therapeutic method with an excellent prognosis rate for various cancer treatments. Unfortunately, a high dose of radiation therapy comes with its own share of side effects, causing radiation-induced… read more here.
Keywords: therapy; neurodegeneration; radiation; radiation induced ... See more keywords
Hypothalamic Estrogen Signaling and Adipose Tissue Metabolism in Energy Homeostasis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.898139
Abstract: Obesity has become a global epidemic, and it is a major risk factor for other metabolic disorders such as type 2 diabetes and cardiometabolic disease. Accumulating evidence indicates that there is sex-specific metabolic protection and… read more here.
Keywords: tissue metabolism; adipose tissue; hypothalamic estrogen; estrogen signaling ... See more keywords
Regulation of ERα Stability and Estrogen Signaling in Breast Cancer by HOIL-1
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.664689
Abstract: Estrogen receptor α (ERα) is the major driver for breast tumor carcinogenesis and progression, while ERα positive breast cancer is the major subtype in breast malignancies, which account for 70% breast cancers in patients. The… read more here.
Keywords: estrogen signaling; hoil; breast; breast cancer ... See more keywords
Anti-Hepatocellular Carcinoma Effect and Molecular Mechanism of the Estrogen Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.763539
Abstract: There are significant gender differences in the incidence and mortality of hepatocellular carcinoma (HCC). Compared with men, the incidence and mortality of HCC in women are relatively low. The estrogen signaling pathway, composed of estrogen… read more here.
Keywords: hepatocellular carcinoma; estrogen; signaling pathway; effect ... See more keywords
Hippocampal Estrogen Signaling Mediates Sex Differences in Retroactive Interference
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10061387
Abstract: Despite being a crucial physiological function of the brain, the mechanisms underlying forgetting are still poorly understood. Estrogens play a critical role in different brain functions, including memory. However, the effects of sex hormones on… read more here.
Keywords: retroactive interference; interference; sex differences; mice ... See more keywords
Assessment of Five Pesticides as Endocrine-Disrupting Chemicals: Effects on Estrogen Receptors and Aromatase
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Environmental Research and Public Health"
DOI: 10.3390/ijerph19041959
Abstract: Pesticides are widely applied all over the world, and pesticide exposure can induce different biological effects posing a possible threat to human health. Due to their effects on the endocrine system, some pesticides are classified… read more here.
Keywords: five pesticides; estrogen biosynthesis; estrogen signaling; pesticides estrogen ... See more keywords
The Role of Estrogen Receptors and Their Signaling across Psychiatric Disorders
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22010373
Abstract: Increasing evidence suggests estrogen and estrogen signaling pathway disturbances across psychiatric disorders. Estrogens are not only crucial in sexual maturation and reproduction but are also highly involved in a wide range of brain functions, such… read more here.
Keywords: role estrogen; across psychiatric; psychiatric disorders; estrogen ... See more keywords