Development and Validation of Predictive Quantitative Structure–Activity Relationship Models for Estrogenic Activities of Hydroxylated Polychlorinated Biphenyls
Sign Up to like & getrecommendations! Published in 2023 at "Environmental Toxicology and Chemistry"
DOI: 10.1002/etc.5566
Abstract: Disruption of the endocrine system by hydroxylated polychlorinated biphenyls (OH‐PCBs) is hypothesized, among other potential mechanisms, to be mediated via nuclear receptor binding. Due to the high cost and lengthy time required to produce high‐quality… read more here.
Keywords: structure activity; quantitative structure; polychlorinated biphenyls; hydroxylated polychlorinated ... See more keywords
Water extract of Er-xian decoction selectively exerts estrogenic activities and interacts with SERMs in estrogen-sensitive tissues.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2021.114096
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE The increasing use of "kidney"-nourishing Traditional Chinese Medicine (TCM) like Er-xian decoction (EXD) for management of menopausal symptoms and osteoporosis has aroused concerns about their safety, and whether they interact with prescription drugs… read more here.
Keywords: estrogenic activities; xian decoction; exd serms; sensitive tissues ... See more keywords