In vivo profiling of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced estrogenic/anti-estrogenic effects in female estrogen-responsive reporter transgenic mice.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of hazardous materials"
DOI: 10.1016/j.jhazmat.2019.121526
Abstract: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), commonly referred to simply as "dioxin", is a persistent environmental pollutant. Because of its high environmental persistence and biological accumulation, humans and animals are often exposed to TCDD. Therefore, the harmful effects on… read more here.
Keywords: anti estrogenic; estrogen; estrogenic effects; tetrachlorodibenzo dioxin ... See more keywords
Design, synthesis, and biological evaluation of steroidal analogs as estrogenic/anti-estrogenic agents
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DOI: 10.1016/j.steroids.2016.11.005
Abstract: HIGHLIGHTSSeries of estrone analogs were synthesized.Cell proliferation, cytotoxicity, and estrogenic/anti‐estrogenic activities were evaluated.LA‐7 alcohol derivative exhibited selective anti‐estrogenic activity towards ER‐&agr; at 5.49 &mgr;M. ABSTRACT Series of estrone based analogs were synthetically investigated at positions… read more here.
Keywords: design synthesis; anti estrogenic; affinity towards; towards agr ... See more keywords