Deletion of ESX-3 and ESX-4 secretion systems in Mycobacterium abscessus results in highly impaired pathogenicity
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DOI: 10.1038/s42003-025-07572-4
Abstract: Type VII secretion systems participate in protein export, virulence, conjugation, and metabolic regulation. Five subtypes (ESX-1 to ESX-5) exist, each with specific roles and well-characterized secretion profiles in various mycobacterial species. Mycobacterium abscessus, encodes only… read more here.
Keywords: pathogenicity; secretion systems; esx esx; esx secretion ... See more keywords
EspC forms a filamentous structure in the cell envelope of Mycobacterium tuberculosis and impacts ESX‐1 secretion
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DOI: 10.1111/mmi.13575
Abstract: Pathogenicity of Mycobacterium tuberculosis (M. tb) is mediated by the ESX‐1 secretion system, which exports EsxA and EsxB, the major virulence factors that are co‐secreted with EspA and EspC. Functional information about ESX‐1 components is… read more here.
Keywords: secretion; cell envelope; filamentous structure; mycobacterium tuberculosis ... See more keywords