Autoimmune activation and hypersensitization of the AT1 and ETA receptors contributes to vascular injury in scleroderma renal crisis.
Sign Up to like & getrecommendations! Published in 2022 at "Rheumatology"
DOI: 10.1093/rheumatology/keac594
Abstract: OBJECTIVES Scleroderma renal crisis (SRC) is a rare vascular complication of systemic sclerosis with substantial risks for end-stage renal disease and premature death. Activating autoantibodies (Abs) targeting the angiotensin II type 1 (AT1R) and the… read more here.
Keywords: vascular injury; etar; renal crisis; scleroderma renal ... See more keywords
Calcitriol attenuates vascular remodeling in association with alteration of ppET-1/ETBR/eNOS and ETAR expression in acute and chronic phases of kidney ischemia-reperfusion injury in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2022-0130
Abstract: Kidney ischemia-reperfusion injury (IRI) causes acute kidney injury with increasing risk of maladaptive repair through endothelin-1/ETAR signaling. Calcitriol shows renoprotection in kidney fibrosis, however, its effects on vasoactive substances expression and vascular remodeling following kidney… read more here.
Keywords: expression; kidney iri; etar; vascular remodeling ... See more keywords
Castration determines the efficacy of ETAR blockade in a mouse model of prostate cancer bone metastasis.
Sign Up to like & getrecommendations! Published in 2019 at "Endocrinology"
DOI: 10.1210/en.2019-00261
Abstract: Bone metastasis is a painful complication of advanced prostate cancer. Endothelin-1 (ET-1) is a tumor-secreted factor that plays a central role in osteoblast activation and the osteosclerotic response of prostate cancer metastatic to bone. Antagonists… read more here.
Keywords: cancer; etar; bone metastasis; prostate cancer ... See more keywords
Antibodies against Angiotensin II Type 1 and Endothelin 1 Type A Receptors in Cardiovascular Pathologies
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DOI: 10.3390/ijms23020927
Abstract: Angiotensin II receptor type 1 (AT1R) and endothelin-1 receptor type A (ETAR) are G-protein-coupled receptors (GPCRs) expressed on the surface of a great variety of cells: immune cells, vascular smooth cells, endothelial cells, and fibroblasts… read more here.
Keywords: cardiovascular pathologies; etar; antibodies angiotensin; angiotensin type ... See more keywords