Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes
Sign Up to like & getrecommendations! Published in 2020 at "Protein & Cell"
DOI: 10.1007/s13238-020-00717-7
Abstract: Obesity is caused by an imbalance between energy intake and expenditure, and has become a global epidemic with over 650 million adults affected. Adipose tissues in mammals are composed of white adipose tissue (WAT) and… read more here.
Keywords: white adipocytes; beige adipocytes; obesity; ethacrynic acid ... See more keywords
Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.8b00250
Abstract: Ethacrynic acid (EA) is a diuretic drug that is widely used to treat high-blood pressure and swelling caused by congestive heart failure or kidney failure. It acts through noncovalent inhibition of the Na+-K+-2Cl- cotransporter in… read more here.
Keywords: adenine nucleotide; mitochondrial function; nucleotide translocases; ethacrynic acid ... See more keywords
Repurposing ethacrynic acid for the treatment of bladder cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.6_suppl.521
Abstract: 521Background: Bladder cancer is a common cancer in the US. Approximately seventy-five percent of new cases present as non-muscle invasive bladder cancer (NMIBC) with a high recurrence rate. Our group has demonstrated in well-characterized human… read more here.
Keywords: bladder cancer; repurposing ethacrynic; bladder; ethacrynic acid ... See more keywords
Improvement of the Chemical Reactivity of Michael Acceptor of Ethacrynic Acid Correlates with Antiproliferative Activities
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28020910
Abstract: The present study aims to report the design, synthesis, and biological activity of new ethacrynic acid (EA) analogs (6–10) obtained by the double modulation of the carboxylic acid moiety and the aromatic ring with the… read more here.
Keywords: reactivity michael; michael acceptor; acid; activity ... See more keywords
Utilizing ethacrynic acid and ciclopirox olamine in liver cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Oncology letters"
DOI: 10.3892/ol.2018.9472
Abstract: Once aberrantly activated, the Wnt/β-catenin pathway may result in uncontrolled proliferation and eventually cancer. Efforts to counter and inhibit this pathway are mainly directed against β-catenin, as it serves a role on the cytoplasm and… read more here.
Keywords: ciclopirox olamine; acid ciclopirox; ethacrynic acid; cancer ... See more keywords