Chronic Ethanol Consumption Alters Glucocorticoid Receptor Isoform Expression in Stress Neurocircuits and Mesocorticolimbic Brain Regions of Alcohol-Preferring Rats
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DOI: 10.1016/j.neuroscience.2020.04.033
Abstract: Evidence suggests the hypothalamic-pituitary-adrenal (HPA) axis is involved in Alcohol Use Disorders (AUDs), which might be mediated by an imbalance of glucocorticoid receptor (GR), GRα and GRβ, activity. GRβ antagonizes the GRα isoform to cause… read more here.
Keywords: isoform expression; ethanol drinking; expression; alcohol preferring ... See more keywords
Kappa-opioid receptor stimulation in the nucleus accumbens shell and ethanol drinking: Differential effects by rostro-caudal location and level of drinking
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DOI: 10.1038/s41386-024-01850-1
Abstract: Although the kappa-opioid receptor (KOR) and its endogenous ligand, dynorphin, are believed to be involved in ethanol drinking, evidence on the direction of their effects has been mixed. The nucleus accumbens (NAc) shell densely expresses… read more here.
Keywords: shell; drinking; drinking females; ethanol drinking ... See more keywords
A history of ethanol drinking increases locomotor stimulation and blunts enhancement of dendritic dopamine transmission by methamphetamine
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DOI: 10.1111/adb.12763
Abstract: Ethanol and psychostimulant use disorders exhibit comorbidity in humans and cross‐sensitization in animal models, but the neurobiological underpinnings of this are not well understood. Ethanol acutely increases dopamine neuron excitability, and psychostimulants such as cocaine… read more here.
Keywords: dendritic dopamine; history ethanol; methamphetamine; ethanol drinking ... See more keywords
Role of suppressing GLT‐1 and xCT in ceftriaxone‐induced attenuation of relapse‐like alcohol drinking in alcohol‐preferring rats
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DOI: 10.1111/adb.13178
Abstract: Alcohol dependence results in long‐lasting neuroadaptive changes in meso‐corticolimbic system, especially in the nucleus accumbens (NAc), which drives relapse‐like ethanol drinking upon abstinence or withdrawal. Within NAc, altered glutamate homeostasis is one of the neuroadaptive… read more here.
Keywords: ethanol drinking; like ethanol; glt xct; relapse like ... See more keywords
Binge ethanol drinking during adolescence modifies cocaine responses in mice
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DOI: 10.1177/0269881116681457
Abstract: Binge ethanol drinking is an emerging pattern of excessive consumption among adolescents and young adults. Repeated ethanol intoxication has negative consequences during critical periods of brain development. Therefore, binge ethanol intake represents a vulnerability factor… read more here.
Keywords: ethanol drinking; adolescence; binge ethanol; ethanol intake ... See more keywords
Binge Ethanol Drinking Produces Sexually Divergent and Distinct Changes in Nucleus Accumbens Signaling Cascades and Pathways in Adult C57BL/6J Mice
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DOI: 10.3389/fgene.2018.00325
Abstract: We previously determined that repeated binge ethanol drinking produced sex differences in the regulation of signaling downstream of Group 1 metabotropic glutamate receptors in the nucleus accumbens (NAc) of adult C57BL/6J mice. The purpose of… read more here.
Keywords: ethanol drinking; binge; binge ethanol; mice ... See more keywords
Sensitivity and Resilience to Predator Stress-Enhanced Ethanol Drinking Is Associated With Sex-Dependent Differences in Stress-Regulating Systems
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Behavioral Neuroscience"
DOI: 10.3389/fnbeh.2022.834880
Abstract: Stress can increase ethanol drinking, and evidence confirms an association between post-traumatic stress disorder (PTSD) and the development of alcohol use disorder (AUD). Exposure to predator odor is considered a traumatic stressor, and predator stress… read more here.
Keywords: ethanol drinking; receptor; stress; crf receptor ... See more keywords
Acute and Protracted Prenatal Stress Produce Mood Disorder-Like and Ethanol Drinking Behaviors in Male and Female Adult Offspring
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Behavioral Neuroscience"
DOI: 10.3389/fnbeh.2022.862390
Abstract: Background Alcohol use disorder (AUD) is a complex and chronic relapsing brain disease, which is often co-morbid with psychiatric disorders such as anxiety and depression. AUD phenotypes differ in men and women. Although genetic factors… read more here.
Keywords: stress; ethanol drinking; like ethanol; male female ... See more keywords