Differential Sensitivity of pHLIP to Ester and Ether Lipids.
Sign Up to like & getrecommendations! Published in 2019 at "Chemistry and physics of lipids"
DOI: 10.1016/j.chemphyslip.2019.104849
Abstract: pH (low) insertion peptide (pHLIP) is a polypeptide from the third transmembrane helix of bacteriorhodopsin. The pH-dependent membrane insertion of pHLIP has been conveniently exploited for translocation of cargo molecules and as a novel imaging… read more here.
Keywords: ester ether; ether lipids; phlip; ester ... See more keywords
Ether lipid deficiency disrupts lipid homeostasis leading to ferroptosis sensitivity
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1010436
Abstract: Ferroptosis is an iron-dependent form of regulated cell death associated with uncontrolled membrane lipid peroxidation and destruction. Previously, we showed that dietary dihomo-gamma-linolenic acid (DGLA; 20: 3(n-6)) triggers ferroptosis in the germ cells of the… read more here.
Keywords: lipid deficiency; ferroptosis sensitivity; deficiency disrupts; ether lipid ... See more keywords
Ether Lipid-Mediated Antioxidant Defense in Alzheimer’s Disease
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DOI: 10.3390/antiox12020293
Abstract: One of the richest tissues in lipid content and diversity of the human body is the brain. The human brain is constitutively highly vulnerable to oxidative stress. This oxidative stress is a determinant in brain… read more here.
Keywords: alzheimer disease; brain; antioxidant defense; human brain ... See more keywords
Overlapping and Distinct Features of Cardiac Pathology in Inherited Human and Murine Ether Lipid Deficiency
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24031884
Abstract: Inherited deficiency in ether lipids, a subgroup of glycerophospholipids with unique biochemical and biophysical properties, evokes severe symptoms in humans resulting in a multi-organ syndrome. Mouse models with defects in ether lipid biosynthesis have widely… read more here.
Keywords: lipid deficient; pathology; lipid deficiency; ether lipids ... See more keywords