Characterisation of the transcriptome of male and female wild-type guppy brains with RNA-Seq and consequences of exposure to the pharmaceutical pollutant, 17α-ethinyl estradiol.
Sign Up to like & getrecommendations! Published in 2017 at "Aquatic toxicology"
DOI: 10.1016/j.aquatox.2017.02.016
Abstract: Waterways are increasingly being contaminated by chemical compounds that can disrupt the endocrinology of organisms. One such compound is 17α-ethinyl estradiol (EE2), a synthetic estrogen used in the contraceptive pill. Despite considerable research interest in… read more here.
Keywords: male female; brain transcriptome; wild type; ethinyl estradiol ... See more keywords
Exposure to 17α-ethinyl estradiol during early pregnancy affects fetal growth and survival in mice.
Sign Up to like & getrecommendations! Published in 2019 at "Environmental pollution"
DOI: 10.1016/j.envpol.2019.04.144
Abstract: 17α-ethinyl estradiol (EE2) is a synthetic compound widely used in the generation of contraceptive pills. EE2 is present in the urine of women taking contraceptives and its presence has been confirmed at increasing concentrations contaminating… read more here.
Keywords: exposure; early pregnancy; mice; ethinyl estradiol ... See more keywords
The Impact of Two Combined Oral Contraceptives Containing Ethinyl Estradiol and Drospirenone on Whole Blood Clot Viscoelasticity and the Biophysical and Biochemical Characteristics of Erythrocytes
Sign Up to like & getrecommendations! Published in 2018 at "Microscopy and Microanalysis"
DOI: 10.1017/s1431927618015453
Abstract: Abstract Venous thrombosis is associated with combined oral contraceptive (COC) use. We investigated the impact of two ethinyl estradiol (EE) and drospirenone (DRSP) containing COCs (3 mg DRSP/20 µg EE and 3 µg DRSP/30 µg… read more here.
Keywords: combined oral; biophysical biochemical; microscopy; ethinyl estradiol ... See more keywords
Genital epithelial barrier function is conserved by intravaginal rings releasing etonogestrel and ethinyl estradiol.
Sign Up to like & getrecommendations! Published in 2023 at "Tissue barriers"
DOI: 10.1080/21688370.2023.2186672
Abstract: The injectable progestin depot-medroxyprogesterone acetate (DMPA) is a popular contraceptive choice in sub-Saharan Africa although mouse models indicate it weakens genital epithelial integrity and barrier function and increases susceptibility to genital infection. The intravaginal ring… read more here.
Keywords: barrier function; function; genital epithelial; ethinyl estradiol ... See more keywords
Evaluation of the potential for pharmacokinetic interaction between tirabrutinib and levonorgestrel/ethinyl estradiol in healthy female volunteers
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Science"
DOI: 10.1111/cts.13265
Abstract: Tirabrutinib (TIRA), a potent and nonreversible oral Bruton tyrosine kinase inhibitor, is evaluated for treatment of certain hematological malignancies and inflammatory diseases. A drug–drug interaction study to evaluate the effect of TIRA on the pharmacokinetics… read more here.
Keywords: interaction; healthy female; tira; levo ... See more keywords
Fostemsavir and ethinyl estradiol drug interaction: Clinical recommendations for co‐administration
Sign Up to like & getrecommendations! Published in 2022 at "HIV Medicine"
DOI: 10.1111/hiv.13442
Abstract: Fostemsavir, a prodrug of temsavir, is indicated for heavily treatment‐experienced adults with multidrug‐resistant HIV‐1 infection, antiretroviral (ARV) intolerance, or safety considerations. Understanding drug–drug interactions (DDIs) is important in individuals taking fostemsavir with hormonal contraceptives or… read more here.
Keywords: interaction clinical; ethinyl estradiol; estradiol drug; drug interaction ... See more keywords
Transcriptomic alterations in the brain of painted turtles (Chrysemys picta) developmentally exposed to bisphenol A or ethinyl estradiol.
Sign Up to like & getrecommendations! Published in 2017 at "Physiological genomics"
DOI: 10.1152/physiolgenomics.00103.2016
Abstract: Developmental exposure of turtles and other reptiles to endocrine-disrupting chemicals (EDCs), including bisphenol A (BPA) and ethinyl estradiol (EE), can stimulate partial to full gonadal sex-reversal in males. We have also recently shown that in… read more here.
Keywords: turtles chrysemys; bpa; brain; transcriptomic alterations ... See more keywords
Extended regimen of a levonorgestrel/ethinyl estradiol transdermal delivery system: Predicted serum hormone levels using a population pharmacokinetic model
Sign Up to like & getrecommendations! Published in 2022 at "PLOS ONE"
DOI: 10.1371/journal.pone.0279640
Abstract: Objective This study employed population pharmacokinetic (popPK) models to predict levonorgestrel (LNG) and ethinyl estradiol (EE) exposure after dosing with the transdermal contraceptive TWIRLA® (LNG/EE TDS) as a 12-week extended regimen in a healthy female… read more here.
Keywords: extended regimen; lng; population pharmacokinetic; ethinyl estradiol ... See more keywords
Oriented bio-feeding control of the anaerobic biodegradation of ethinyl estradiol.
Sign Up to like & getrecommendations! Published in 2022 at "Chemosphere"
DOI: 10.2139/ssrn.4102662
Abstract: Up to 95% of hormones are excreted into domestic wastewater with urine or feces, but their macromolecules are difficult to biodegrade. This project studies the treatment of Ethinyl Estradiol (EE2) in swine wastewater in an… read more here.
Keywords: propionic acid; anaerobic biodegradation; acid; ethinyl estradiol ... See more keywords
Cycle control with an extended-regimen oral contraceptive combining levonorgestrel and ethinyl estradiol that includes continuous low-dose ethinyl estradiol instead of the traditional hormone-free interval
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Women's Health"
DOI: 10.2147/ijwh.s142078
Abstract: Purpose To evaluate scheduled and unscheduled bleeding and spotting over 1 year of treatment with 91-day extended-regimen combined oral contraception (COC) providing continuous low-dose ethinyl estradiol (EE) in place of the traditional 7-day hormone-free interval… read more here.
Keywords: cycle; day; ethinyl estradiol; extended regimen ... See more keywords
Estradiol, Estrone and Ethinyl Estradiol Metabolism Studied by High Resolution LC-MS/MS Using Stable Isotope Labeling and Trapping of Reactive Metabolites
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12100931
Abstract: Biotransformation reactions that xenobiotics undergo during their metabolism are crucial for their proper excretion from the body, but can also be a source of toxicity, especially in the case of reactive metabolite formation. Unstable, reactive… read more here.
Keywords: metabolism; high resolution; estradiol estrone; ethinyl estradiol ... See more keywords