DNA binding and antiradical potential of ethyl pyruvate: Key to the DNA radioprotection.
Sign Up to like & getrecommendations! Published in 2020 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2020.109313
Abstract: DNA is the store house of all necessary hereditary information for growth of cells and tissues. Physiological functionality of DNA depends on its 3D helical structure and any distortion in a structure may lead to… read more here.
Keywords: dna; radioprotection; ethyl pyruvate; plasmid dna ... See more keywords
Protective effect of ethyl pyruvate on gut barrier function through regulations of ROS-related NETs formation during sepsis.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular immunology"
DOI: 10.1016/j.molimm.2021.01.012
Abstract: BACKGROUND Sepsis impairs the function of the intestinal barrier through neutrophil extracellular traps (NETs). Reactive oxygen species (ROS)-induced activation of mitogen-activated protein kinase (MAPK) is involved in NET formation. Ethyl pyruvate (EP), a potent and… read more here.
Keywords: sepsis; barrier; ethyl pyruvate; formation sepsis ... See more keywords
Ethyl pyruvate inhibits oxidation of LDL in vitro and attenuates oxLDL toxicity in EA.hy926 cells
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0191477
Abstract: Background Ethyl pyruvate (EP) exerts anti-inflammatory and anti-oxidative properties. The aim of our study was to investigate whether EP is capable of inhibiting the oxidation of LDL, a crucial step in atherogenesis. Additionally, we examined… read more here.
Keywords: hy926; ethyl pyruvate; hy926 cells; oxidation ldl ... See more keywords
HMGB1 targeting by ethyl pyruvate suppresses malignant phenotype of human mesothelioma
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.15152
Abstract: Human malignant mesothelioma (MM) is an aggressive cancer linked to asbestos and erionite exposure. We previously reported that High-Mobility Group Box-1 protein (HMGB1), a prototypic damage-associated molecular pattern, drives MM development and sustains MM progression.… read more here.
Keywords: hmgb1; mesothelioma; ethyl pyruvate; growth ... See more keywords
Protective effect of ethyl pyruvate on amikacin-induced ototoxicity in rats.
Sign Up to like & getrecommendations! Published in 2022 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202204_28480
Abstract: OBJECTIVE Amikacin (AMK) is a widely used antibiotic, but its ototoxic side effects limit its use. This study investigated the effects of ethyl pyruvate (EP), known for its antioxidant and anti-inflammatory effects, against AMK ototoxicity.… read more here.
Keywords: amikacin; ethyl pyruvate; group; ototoxicity ... See more keywords
Ethyl Pyruvate Modulates Murine Dendritic Cell Activation and Survival Through Their Immunometabolism
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.00030
Abstract: Attenuating the innate immunity activation could ameliorate inflammation and disease in settings such as transplant rejection or autoimmunity. Recently, a pivotal role for metabolic re-programming in TLR-induced dendritic cell (DC) activation has emerged. Ethyl pyruvate… read more here.
Keywords: ethyl pyruvate; cell activation; activation; cell ... See more keywords
Ethyl Pyruvate Induces Tolerogenic Dendritic Cells
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.00157
Abstract: Dendritic cells (DC) are professional antigen presenting cells that have a key role in shaping the immune response. Tolerogenic DC (tolDC) have immuno-regulatory properties and they are a promising prospective therapy for multiple sclerosis and… read more here.
Keywords: pyruvate induces; ethyl pyruvate; dendritic cells; multiple sclerosis ... See more keywords
Protective role of ethyl pyruvate in spinal cord injury by inhibiting the high mobility group box-1/toll-like receptor4/nuclear factor-kappa B signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.1013033
Abstract: Spinal cord injury (SCI) is a high incident rate of central nervous system disease that usually causes paralysis below the injured level. The occurrence of chronic inflammation with the axonal regeneration difficulties are the underlying… read more here.
Keywords: cord injury; mobility group; ethyl pyruvate; high mobility ... See more keywords
Ethyl pyruvate inhibits glioblastoma cells migration and invasion through modulation of NF-κB and ERK-mediated EMT
Sign Up to like & getrecommendations! Published in 2020 at "PeerJ"
DOI: 10.7717/peerj.9559
Abstract: Background Glioblastoma is a grade IV glioma with the highest degree of malignancy and extremely high incidence. Because of the poor therapeutic effect of surgery and radiochemotherapy, glioblastoma has a high recurrence rate and lethality,… read more here.
Keywords: invasion; erk; ethyl pyruvate; u87 u251 ... See more keywords