Identification of non-charged 7.44 analogs interacting with the NHR2 domain of RUNX1-ETO with improved antiproliferative effect in RUNX-ETO positive cells
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DOI: 10.1038/s41598-025-02422-z
Abstract: The RUNX1/ETO fusion protein is a chimeric transcription factor in acute myeloid leukemia (AML) created by chromosomal translocation t(8;21)(q22;q22). t(8;21) abnormality is associated with 12% of de novo AML cases and up to 40% in… read more here.
Keywords: eto positive; runx1 eto; eto; nhr2 domain ... See more keywords
Inhibition of the mutated c-KIT kinase in AML1-ETO-positive leukemia cells restores sensitivity to PARP inhibitor.
Sign Up to like & getrecommendations! Published in 2019 at "Blood advances"
DOI: 10.1182/bloodadvances.2019000756
Abstract: c-KIT activating mutations cause resistance to PARP inhibitor in AML1-ETO–positive leukemias. c-KIT inhibitor avapritinib downregulates BRCA1/2 and DNA-PK catalytic subunit to restore the sensitivity to PARP inhibitor. read more here.
Keywords: aml1 eto; inhibitor; eto positive; sensitivity parp ... See more keywords
Amyloid precursor protein has clinical and prognostic significance in AML1-ETO-positive acute myeloid leukemia
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DOI: 10.3892/ol.2017.7396
Abstract: Amyloid precursor protein (APP) has been reported to be highly expressed in acute myeloid leukemia (AML)1-eight-twenty one (ETO)-positive AML. In the present study, the clinical and prognostic significance of APP expression was assessed in 65… read more here.
Keywords: aml1 eto; eto positive; precursor protein; amyloid precursor ... See more keywords
Gene mutation profile and risk stratification in AML1-ETO-positive acute myeloid leukemia based on next-generation sequencing
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DOI: 10.3892/or.2019.7375
Abstract: Gene mutations play an important role in the development and progression of AML1-ETO-positive acute myeloid leukemia (AE-AML). Nevertheless, the gene mutation profile in this subtype of leukemia remains unclear. In addition, the clinical and prognostic… read more here.
Keywords: aml1 eto; eto positive; positive acute; gene ... See more keywords
A Case of AML1-ETO Positive Acute Myeloid Leukemia Morphologically Similar to Chronic Myelogenous Leukemia.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical laboratory"
DOI: 10.7754/clin.lab.2022.220914
Abstract: BACKGROUND The goal was to study the role of the morphology, immunophenotype, karyotype and fusion gene expression in a patient with diagnosis of AML1-ETO positive acute myeloid leukemia. METHODS A case of AML1-ETO positive acute… read more here.
Keywords: myeloid leukemia; leukemia; expression; aml1 eto ... See more keywords