The NFIA-ETO2 fusion blocks erythroid maturation and induces pure erythroid leukemia in cooperation with mutant TP53.
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DOI: 10.1182/blood.2022017273
Abstract: The NFIA-ETO2 fusion is the product of a t(1;16)(p31;q24) chromosomal translocation so far exclusively found in pediatric patients with pure erythroid leukemia (PEL). To address the role for the pathogenesis of the disease, we expressed… read more here.
Keywords: erythroid differentiation; eto2 fusion; erythroid leukemia; nfia eto2 ... See more keywords