[Comparison of granisetron and lidocaine on reducing injection pain of etomidate: a controlled randomized study].
Sign Up to like & getrecommendations! Published in 2017 at "Revista Brasileira De Anestesiologia"
DOI: 10.1016/j.bjane.2017.04.001
Abstract: Abstract Background and objectives Reducing pain on injection of anesthetic drugs is of importance to every anesthesiologist. In this study we pursued to define if pretreatment by granisetron reduces the pain on injection of etomidate… read more here.
Keywords: etomidate; study; injection; lidocaine ... See more keywords
Metabolite‐inactive etomidate analogues alleviating suppression on adrenal function in Beagle dogs
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2016.12.041
Abstract: Abstract Owing to rapid generation in body, the metabolites of etomidate softdrug are able to accumulate in either the brain or periphery and subsequently affect the recovery from anaesthesia or cause corticosteroid suppression. This study… read more here.
Keywords: etomidate; suppression; beagle dogs; metabolite inactive ... See more keywords
Film-injection as a dosage form for etomidate: Enhancing the stability of nanomedicines using solid intermediate products
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2020.101541
Abstract: Abstract The colloidal stability problem is one of the major obstacles for bench-to-bedside translation of many nanomedicines. Herein, we developed a new strategy that adopted a novel dosage form called “film-injection”. Etomidate, a first-line general… read more here.
Keywords: etomidate; film injection; film; dosage form ... See more keywords
Photomotor Responses in Zebrafish and Electrophysiology Reveal Varying Interactions of Anesthetics Targeting Distinct Sites on γ-Aminobutyric Acid Type A Receptors
Sign Up to like & getrecommendations! Published in 2022 at "Anesthesiology"
DOI: 10.1097/aln.0000000000004361
Abstract: Background: Etomidate, barbiturates, alfaxalone, and propofol are anesthetics that allosterically modulate γ-aminobutyric acid type A (GABAA) receptors via distinct sets of molecular binding sites. Two-state concerted coagonist models account for anesthetic effects and predict supra-additive… read more here.
Keywords: gabaa receptors; aminobutyric acid; photomotor responses; etomidate ... See more keywords
Etomidate Is a First-Line Induction Agent in Critically Ill Patients.
Sign Up to like & getrecommendations! Published in 2018 at "Critical Care Medicine"
DOI: 10.1097/ccm.0000000000003290
Abstract: The selection of medications to facilitate safe emergency airway management (EAM) in critically ill patients poses a considerable challenge for clinicians. Concomitant shock, exhaustion of respiratory reserves, and aspiration risk conspire alongside anatomic and environmental… read more here.
Keywords: etomidate; ill patients; critically ill; induction agent ... See more keywords
Determination of etomidate and etomidate acid in hair using liquid chromatography–tandem mass spectrometry
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Forensic Sciences"
DOI: 10.1111/1556-4029.15113
Abstract: Etomidate, with efficacy similar to that of propofol, has been used as a propofol substitute because propofol is a designated narcotic drug, and an increase in the frequency of illegal distribution and misuse has been… read more here.
Keywords: hair; etomidate; etomidate acid; determination ... See more keywords
Etomidate Induced Seizure: Adverse Drug Event Case Report.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmacy practice"
DOI: 10.1177/0897190020958243
Abstract: OBJECTIVE/PURPOSE To report a case of etomidate induced seizure in a patient that received 0.15 mg/kg of etomidate for a procedural sedation which resolved without intervention. SUMMARY A 68-year-old woman presented to the emergency department… read more here.
Keywords: etomidate; case; report; etomidate induced ... See more keywords
Behavioral and steroidogenic pharmacology of phenyl ring substituted etomidate analogs in rats
Sign Up to like & getrecommendations! Published in 2019 at "BMC Pharmacology & Toxicology"
DOI: 10.1186/s40360-019-0328-4
Abstract: BackgroundCushing’s syndrome is an endocrine disorder characterized by the overproduction of adrenocortical steroids. Steroidogenesis enzyme inhibitors are the mainstays of pharmacological treatment. Unfortunately, they produce significant side effects. Among the most potent inhibitors is the… read more here.
Keywords: etomidate; phenyl ring; etomidate analogs; pharmacology ... See more keywords
Propofol decreased the etomidate-induced myoclonus in adult patients: a meta-analysis and systematic review.
Sign Up to like & getrecommendations! Published in 2023 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202302_31366
Abstract: OBJECTIVE Myoclonus is one of the main complications of etomidate anesthesia, which would develop into serious consequences during surgery. The present analysis was performed to evaluate systematically the effect of propofol on preventing etomidate-induced myoclonus… read more here.
Keywords: etomidate induced; propofol; etomidate; induced myoclonus ... See more keywords
Behavioural Aversion and Cortisol Level Assessment When Adult Zebrafish Are Exposed to Different Anaesthetics
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11101433
Abstract: Simple Summary The increased popularity of zebrafish as a research model calls for appropriate refinement of procedures, such as finding the best anaesthetic protocol to use in adult zebrafish in a laboratory setting. The scarce… read more here.
Keywords: adult zebrafish; aversion; etomidate; cortisol ... See more keywords
Simultaneous Determination of Etomidate and Its Major Metabolite, Etomidate Acid, in Urine Using Dilute and Shoot Liquid Chromatography–Tandem Mass Spectrometry
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24244459
Abstract: Etomidate (ET) is a commonly used sedative-hypnotic agent such as propofol to induce anesthesia, and it is rapidly metabolized to etomidate acid (ETA) in liver. Herein, a simple method to determine ET and ETA in… read more here.
Keywords: chromatography; chromatography tandem; etomidate acid; etomidate ... See more keywords