Metabolic Profile of Etomidate and Its Three Analogs in Zebrafish, Human Liver Microsomes, Human Urine and Hair Samples Using UHPLC-Q Exactive Orbitrap-HRMS.
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DOI: 10.1002/dta.3869
Abstract: Etomidate is a short-acting non-barbiturate imidazole used as an intravenous anesthetic agent in humans, while metomidate and propoxate are common anesthetic drug for fishes. Today, etomidate, and its analogs, including isopropoxate, are increasingly abused, leading… read more here.
Keywords: human urine; analogs zebrafish; liver microsomes; human liver ... See more keywords
Behavioral and steroidogenic pharmacology of phenyl ring substituted etomidate analogs in rats
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DOI: 10.1186/s40360-019-0328-4
Abstract: BackgroundCushing’s syndrome is an endocrine disorder characterized by the overproduction of adrenocortical steroids. Steroidogenesis enzyme inhibitors are the mainstays of pharmacological treatment. Unfortunately, they produce significant side effects. Among the most potent inhibitors is the… read more here.
Keywords: etomidate; phenyl ring; etomidate analogs; pharmacology ... See more keywords
TD-ESI-MS/MS for High-Throughput Screening of 13 Common Drugs and 4 Etomidate Analogs in Hair: Method Validation and Forensic Applications
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DOI: 10.3390/toxics13050329
Abstract: This study established a dual analytical workflow integrating thermal desorption–electrospray ionization–tandem mass spectrometry (TD-ESI-MS/MS) for rapid qualitative screening and ultra-performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS) for confirmatory quantification of 17 psychoactive substances and metabolites across… read more here.
Keywords: high throughput; analogs hair; validation; etomidate analogs ... See more keywords