Pharmacokinetics of darunavir/cobicistat and etravirine alone and co-administered in HIV-infected patients
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkx459
Abstract: Objectives To determine the effect of etravirine on the pharmacokinetics of darunavir/cobicistat and vice versa. Safety and tolerability of this combination were also evaluated. Methods Open-label, fixed-sequence trial in two cohorts of HIV-infected patients on… read more here.
Keywords: darunavir cobicistat; darunavir; cohort; pharmacokinetics darunavir ... See more keywords
Pharmacokinetics of Temsavir, the Active Moiety of the HIV-1 Attachment Inhibitor Prodrug, Fostemsavir, Coadministered with Cobicistat, Etravirine, Darunavir/Cobicistat, or Darunavir/Ritonavir with or without Etravirine in Healthy Participants
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DOI: 10.1128/aac.02251-21
Abstract: Fostemsavir is a prodrug of temsavir, a first-in-class attachment inhibitor that binds directly to HIV-1 gp120, preventing initial viral attachment and entry into host CD4+ T cells with demonstrated efficacy in phase 2 and 3.… read more here.
Keywords: attachment; fostemsavir; drv; cobicistat ... See more keywords