PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer
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DOI: 10.1073/pnas.1822001116
Abstract: Significance PD-1 blockade is a cancer immunotherapy effective in various types of cancer. However, we observed rapid cancer progression, called hyperprogressive disease (HPD), in ∼10% of advanced gastric cancer patients treated with anti–PD-1 monoclonal antibody.… read more here.
Keywords: blockade; hpd; etreg cells; cancer ... See more keywords