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   Articles with "ets1" as a keyword



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Knocking down ETS Proto-oncogene 1 (ETS1) alleviates the pyroptosis of renal tubular epithelial cells in patients with acute kidney injury by regulating the NLR family pyrin domain containing 3 (NLRP3) transcription

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recommendations! Published in 2022 at "Bioengineered"

DOI: 10.1080/21655979.2022.2079242

Abstract: ABSTRACT Acute kidney injury (AKI) has a high mortality rate, but its pathogenesis remains unclear Lipopolysaccharide (LPS)-mediated renal tubular epithelial pyroptosis is involved in the pathogenesis of AKI. NLR family of pyrin domains containing 3… read more here.

Keywords: ets1; transcription; pyroptosis; renal tubular ... See more keywords
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Distinct Prognostic and Immunological Roles of ETS1 and ETS2: A Pan-Cancer Analysis

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recommendations! Published in 2023 at "BioMed Research International"

DOI: 10.1155/2023/4343350

Abstract: Objective ETS1 and ETS2, the main ETS family of transcription factors, have been found to act as downstream effectors of the RAS/MAPK pathway. This study explores the expression and prognostic values of ETS1 and ETS2… read more here.

Keywords: ets1 ets2; ets1; expression; immune cells ... See more keywords
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Abstract A34: Induction of a novel ETS1/FAK pathway in metastasizing ovarian cancer cells by the omental microenvironment primes them for metastatic colonization

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recommendations! Published in 2018 at "Clinical Cancer Research"

DOI: 10.1158/1557-3265.ovca17-a34

Abstract: Metastatic colonization of ovarian cancer involves productive paracrine/juxtacrine interactions with the microenvironment. The resulting induction of an adaptive response in the cancer cells enables them to establish themselves in the new microenvironment and take advantage… read more here.

Keywords: metastatic colonization; ovarian cancer; cancer cells; cancer ... See more keywords
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GATA4 Regulates Developing Endocardium Through Interaction With ETS1

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recommendations! Published in 2022 at "Circulation Research"

DOI: 10.1161/circresaha.120.318102

Abstract: Background: The pioneer transcription factor (TF) GATA4 (GATA Binding Protein 4) is expressed in multiple cardiovascular lineages and is essential for heart development. GATA4 lineage-specific occupancy in the developing heart underlies its lineage specific activities.… read more here.

Keywords: cell; lineage specific; gata4 regulation; ets1 ... See more keywords
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Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction

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recommendations! Published in 2022 at "Circulation Research"

DOI: 10.1161/circresaha.121.319955

Abstract: Rationale: Jacobsen syndrome is a rare chromosomal disorder caused by deletions in the long arm of human chromosome 11, resulting in multiple developmental defects including congenital heart defects. Combined studies in humans and genetically engineered… read more here.

Keywords: ets1; development; coronary vascular; heart ... See more keywords
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Ets1 Enhances Context-Dependent Notch1 Activity in T-Cell Leukemia

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recommendations! Published in 2018 at "Blood"

DOI: 10.1182/blood-2018-99-111376

Abstract: The discovery of NOTCH1 as the most frequently mutated oncogene in T-ALL patients raised hopes for targeted therapy in this cancer. Unfortunately, in clinical trials, the pan-Notch inhibitor GSI caused excessive GI toxicity. Mice treated… read more here.

Keywords: inhibition; notch; proliferation; deletion ... See more keywords

ETS1 is associated with cisplatin resistance through IKKα/NF-κB pathway in cell line MDA-MB-231

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recommendations! Published in 2018 at "Cancer Cell International"

DOI: 10.1186/s12935-018-0581-4

Abstract: BackgroundPlatinum-based drugs are used extensively in neoadjuvant chemotherapy for triple-negative breast cancer (TNBC), but their use can be limited by resistance. In this study, we established cisplatin (DDP) resistant TNBC cells to investigate the potential… read more here.

Keywords: cell line; ddp; mda 231; 231 ddp ... See more keywords
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Molecular dissection of the oncogenic role of ETS1 in the mesenchymal subtypes of head and neck squamous cell carcinoma

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recommendations! Published in 2019 at "PLoS Genetics"

DOI: 10.1371/journal.pgen.1008250

Abstract: Head and Neck Squamous Cell Carcinoma (HNSCC) is a heterogeneous disease of significant mortality and with limited treatment options. Recent genomic analysis of HNSCC tumors has identified several distinct molecular classes, of which the mesenchymal… read more here.

Keywords: neck squamous; squamous cell; role; ets1 ... See more keywords
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Phosphorylation-mediated interaction between human E26 transcription factor 1 and specific protein 1 is required for tumor cell migration

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recommendations! Published in 2022 at "Acta Biochimica et Biophysica Sinica"

DOI: 10.3724/abbs.2022148

Abstract: Transcription factors, human E26 transcription factor 1 (Ets1) and specific protein 1 (Sp1), are known to induce gene expression in tumorigenicity. High Ets1 expression is often associated with colorectal tumorigenesis. In this study, we discover… read more here.

Keywords: interaction; ets1; transcription; human e26 ... See more keywords