Strong cytoplasmic ETV1 expression has a negative impact on prostate cancer outcome
Sign Up to like & getrecommendations! Published in 2019 at "Virchows Archiv"
DOI: 10.1007/s00428-019-02573-1
Abstract: Overexpression of ETS genes is involved in prostate cancer (PrCa), but there is little information on the non-ERG components of this family. We have investigated ETV1, ETV4, and ETV5 overexpression, with or without PTEN loss,… read more here.
Keywords: expression negative; overexpression; etv1; prostate cancer ... See more keywords
Identification of phenothiazine as an ETV1‑targeting agent in gastrointestinal stromal tumors using the Connectivity Map.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of oncology"
DOI: 10.3892/ijo.2019.4829
Abstract: Gastrointestinal stromal tumors (GISTs) are gastrointestinal tract sarcomas that commonly contain a mutation in the tyrosine kinases, KIT and platelet‑derived growth factor receptor A (PDGFRA). Imatinib, sunitinib and regorafenib are all effective tyrosine kinase inhibitors; however, acquired… read more here.
Keywords: phenothiazine; connectivity map; etv1; gastrointestinal stromal ... See more keywords