3106 – DIRECT INDUCTION OF HEMOGENIC ENDOTHELIUM AND MYELOID CELLS FROM HUMAN IPSCS USING ETV2 MODIFIED RNA
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2020.09.118
Abstract: Previously, we demonstrated that overexpressing transcription factors ETV2 and GATA2 is sufficient to induce a pan-myeloid program in human induced pluripotent stem cells (hiPSCs), which proceeds through a hemogenic endothelium (HE) stage (Elcheva et al.,… read more here.
Keywords: myeloid; etv2; presence csf; hemogenic endothelium ... See more keywords
Abstract 374: Etv2 Transcriptionally Regulates Yes1 and Promotes Cell Proliferation During Embryogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Circulation Research"
DOI: 10.1161/res.125.suppl_1.374
Abstract: Etv2, an Ets-transcription factor, governs the specification of the earliest hemato-endothelial progenitors during embryogenesis. While the transcriptional networks during hemato-endothelial development have been well described, the mechanistic details are incompletely defined. In the present study,… read more here.
Keywords: embryogenesis; cell cycle; proliferation; yes1 ... See more keywords
ETV2 and VEZF1 interaction and regulation of the hematoendothelial lineage during embryogenesis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1109648
Abstract: Ets variant 2 (Etv2), a member of the Ets factor family, has an essential role in the formation of endothelial and hematopoietic cell lineages during embryonic development. The functional role of ETS transcription factors is,… read more here.
Keywords: interaction; etv2; vezf1; lineage ... See more keywords