Novel ETV6-RUNX1 Mouse Model to Study the Role of ELF-MF in Childhood B-Acute Lymphoblastic Leukemia: a Pilot Study.
Sign Up to like & getrecommendations! Published in 2019 at "Bioelectromagnetics"
DOI: 10.1002/bem.22193
Abstract: Exposure to extremely low-frequency magnetic fields (ELF-MFs) has been classified by the International Agency for Research on Cancer (IARC) as "possibly carcinogenic to humans," based on limited scientific evidence concerning childhood leukemia. This assessment emphasized… read more here.
Keywords: etv6 runx1; runx1; study; leukemia ... See more keywords
ETV6-RUNX1 interacts with a region in SPIB intron 1 to regulate gene expression in pre-B-cell acute lymphoblastic leukemia.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental hematology"
DOI: 10.1016/j.exphem.2019.03.004
Abstract: The most frequently occurring genetic abnormality in pediatric B-lymphocyte-lineage acute lymphoblastic leukemia is the t(12;21) chromosomal translocation that results in a ETV6-RUNX1 (also known as TEL-AML1) fusion gene. Expression of ETV6-RUNX1 induces a preleukemic condition… read more here.
Keywords: etv6 runx1; expression; cell; gene expression ... See more keywords
Minimal residual disease monitoring in childhood B lymphoblastic leukemia with t(12;21)(p13;q22); ETV6–RUNX1: concordant results using quantitation of fusion transcript and flow cytometry
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DOI: 10.1111/ijlh.12593
Abstract: The translocation t(12;21)(p13;q22) resulting in the fusion gene ETV6–RUNX1, is the most frequent gene fusion in childhood B lymphoblastic leukemia. In the Nordic Society of Paediatric Haematology and Oncology ALL‐2008 treatment protocol, treatment stratification in… read more here.
Keywords: etv6 runx1; minimal residual; p13 q22; lymphoblastic leukemia ... See more keywords
Abstract 2992: Conserved gene fusion ETV6/RUNX1 displays higher immunogenicity than patient-specific missense mutations within the context of HLA-A*02:01
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2992
Abstract: Tumor-specific antigens can be targeted by T cells and cancer immunotherapies directed against these neoantigens have resulted in regression across several cancer types. Both missense mutations and gene fusions can serve as targets for cytotoxic… read more here.
Keywords: fusion; hla; missense mutations; etv6 runx1 ... See more keywords
A somatic UBA2 variant preceded ETV6-RUNX1 in the concordant BCP-ALL of monozygotic twins
Sign Up to like & getrecommendations! Published in 2022 at "Blood Advances"
DOI: 10.1182/bloodadvances.2021005703
Abstract: Key Points A somatic UBA2 deletion preceded the well-established leukemia initiating event ETV6-RUNX1 fusion in monozygotic twins with BCP-ALL. A shared complex rearrangement created an ETV6-RUNX1 fusion and provided evidence of a common clonal in… read more here.
Keywords: somatic uba2; etv6 runx1; variant preceded; monozygotic twins ... See more keywords
Investigation of lncRNA-mRNA co-expression network in ETV6-RUNX1-positive pediatric B-cell acute lymphoblastic leukemia
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DOI: 10.1371/journal.pone.0253012
Abstract: ETV6/RUNX1 gene fusion is the most common chromosomal translocation abnormality occurred in pediatric B-cell acute lymphoblastic leukemia (B-ALL). Compared with ETV6-RUNX1-negative patients, ETV6-RUNX1-positive patients possess more improved treatment strategies but higher risk to relapse. In… read more here.
Keywords: etv6 runx1; runx1 positive; lncrna mrna; expression ... See more keywords
TP53, ETV6 and RUNX1 germline variants in a case series of patients developing secondary neoplasms after treatment for childhood acute lymphoblastic leukemia
Sign Up to like & getrecommendations! Published in 2019 at "Haematologica"
DOI: 10.3324/haematol.2018.205849
Abstract: Today, most children with acute lymphoblastic leukemia (ALL) can be cured by treatment regimens consisting of combination chemotherapy supplemented in certain patient populations with preventive or therapeutic cranial irradiation (CI) and/or an allogeneic hematopoietic stem… read more here.
Keywords: etv6 runx1; treatment; lymphoblastic leukemia; tp53 etv6 ... See more keywords
Diagnostic Utility of IGF2BP1 and Its Targets as Potential Biomarkers in ETV6-RUNX1 Positive B-Cell Acute Lymphoblastic Leukemia
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.588101
Abstract: Around 85% of childhood Acute Lymphoblastic Leukemia (ALL) are of B-cell origin and characterized by the presence of different translocations including BCR-ABL1, ETV6-RUNX1, E2A-PBX1, and MLL fusion proteins. The current clinical investigations used to identify… read more here.
Keywords: etv6 runx1; utility; lymphoblastic leukemia; acute lymphoblastic ... See more keywords