CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
Sign Up to like & getrecommendations! Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2017.04.005
Abstract: The CRISPR-Cas9 RNA-guided DNA endonuclease has contributed to an explosion of advances in the life sciences that have grown from the ability to edit genomes within living cells. In this Review, we summarize CRISPR-based technologies… read more here.
Keywords: crispr based; technologies manipulation; manipulation eukaryotic; based technologies ... See more keywords
Transposable elements drive intron gain in diverse eukaryotes
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2209766119
Abstract: There is massive variation in intron numbers across eukaryotic genomes, yet the major drivers of intron content during evolution remain elusive. Rapid intron loss and gain in some lineages contrasts with long term evolutionary stasis… read more here.
Keywords: intron; elements drive; transposable elements; gain ... See more keywords
Transposable elements employ distinct integration strategies with respect to transcriptional landscapes in eukaryotic genomes
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa370
Abstract: Abstract Transposable elements (TEs) are ubiquitous DNA segments capable of moving from one site to another within host genomes. The extant distributions of TEs in eukaryotic genomes have been shaped by both bona fide TE… read more here.
Keywords: integration; precision targeting; eukaryotic genomes; elements employ ... See more keywords
Heterochromatin: did H3K9 methylation evolve to tame transposons?
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DOI: 10.1186/s13059-021-02550-5
Abstract: * Correspondence: guillaume.filion@ utoronto.ca Department of Biological Sciences, University of Toronto Scarborough, 1265 Military Trail, Scarborough, M1C1A4 ON, Canada Chromatin is traditionally studied in the fields of DNA repair and gene regulation, not immunology. Yet,… read more here.
Keywords: chromatin; h3k9 methylation; methylation; non ltr ... See more keywords