Comprehensive analysis of biological networks and the eukaryotic initiation factor 4A-3 gene as pivotal in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.29596
Abstract: Eukaryotic initiation factor 4A-3 (EIF4A3) is a core component of the exon junction complex (EJC). Abnormalities in EIF4A3 are associated with carcinogenesis. The present study aimed to determine the biological role of EIF4A3 in hepatocellular… read more here.
Keywords: hepatocellular carcinoma; eukaryotic initiation; analysis; initiation factor ... See more keywords
Eukaryotic initiation factor 4E is a novel effector of mTORC1 signaling pathway in cross talk with Mnk1
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-019-03663-z
Abstract: Cellular signals that influence Cap-dependent translation have assumed significant relevance in the backdrop of their enforced dysregulation during oncogenesis. Eukaryotic initiation factor 4E(eIF4E), the mRNA cap-binding protein, has emerged as a key player to facilitate… read more here.
Keywords: initiation factor; phosphorylation; eukaryotic initiation; cap dependent ... See more keywords
Eukaryotic initiation factor 2 signaling behind neural invasion linked with lymphatic and vascular invasion in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-00727-3
Abstract: Perineural invasion (PNI) is a typical poor prognostic factor in pancreatic ductal adenocarcinoma (PDAC). The mechanisms linking PNI to poor prognosis remain unclear. This study aimed to clarify what changes occurred alongside PNI in PDAC.… read more here.
Keywords: eukaryotic initiation; pdac; invasion; initiation factor ... See more keywords
Therapeutic targeting of eukaryotic initiation factor (eIF) 4E.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemical Society transactions"
DOI: 10.1042/bst20220285
Abstract: Fundamental studies unraveled the role of eukaryotic initiation factor (eIF) 4E in mRNA translation and its control. Under physiological conditions, regulation of translation by eIF4E is essential to cellular homeostasis. Under stress, gene flow information… read more here.
Keywords: factor eif; therapeutic targeting; eukaryotic initiation; initiation factor ... See more keywords
A close-up view of codon selection in eukaryotic initiation
Sign Up to like & getrecommendations! Published in 2017 at "RNA Biology"
DOI: 10.1080/15476286.2017.1308998
Abstract: ABSTRACT When given an option to choose among a set of alternatives and only one selection is right, one might stop and reflect over which one is best. However, the ribosome has no time to… read more here.
Keywords: eukaryotic initiation; initiation; selection; codon ... See more keywords
Eukaryotic initiation factor 4F promotes a reorientation of eukaryotic initiation factor 3 binding on the 5′ and the 3′ UTRs of barley yellow dwarf virus mRNA
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac284
Abstract: Abstract Viral mRNAs that lack a 5′ m7GTP cap and a 3′ poly-A tail rely on structural elements in their untranslated regions (UTRs) to form unique RNA-protein complexes that regulate viral translation. Recent studies of… read more here.
Keywords: initiation factor; factor; eukaryotic initiation; bydv ... See more keywords
Eukaryotic initiation factor 6 modulates the metamorphosis and reproduction of Tribolium castaneum
Sign Up to like & getrecommendations! Published in 2022 at "Insect Molecular Biology"
DOI: 10.1111/imb.12817
Abstract: Eukaryotic initiation factor 6 (eIF6) is necessary for ribosome biogenesis and translation, but eIF6 has been poorly elucidated in insects. Phylogenetic analysis demonstrated that eIF6 originated from one ancestral gene among animals and exhibited specific… read more here.
Keywords: metamorphosis reproduction; initiation factor; expression; castaneum ... See more keywords
Effect of knockdown of eukaryotic initiation factor 4A2 (eIF4A2) on growth, metastasis, and oxaliplatin sensitivity in colorectal cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e15658
Abstract: e15658Background: Our previous study found that eIF4A2 was highly expressed in colorectal cancer and high eIF4A2 expression predicted poor prognosis, which was reported in ASCO GI 2018. However, th... read more here.
Keywords: eif4a2; effect knockdown; eukaryotic initiation; colorectal cancer ... See more keywords
Eukaryotic Initiation Factor 4A-3: A Review of Its Physiological Role and Involvement in Oncogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.712045
Abstract: EIF4A3, a member of the DEAD-box protein family, is a nuclear matrix protein and a core component of the exon junction complex (EJC). Under physiological conditions, EIF4A3 participates in post-transcriptional gene regulation by promoting EJC… read more here.
Keywords: physiological role; initiation factor; eukaryotic initiation; review physiological ... See more keywords
Effects of Essential Amino Acid Deficiency on General Control Nonderepressible 2/Eukaryotic Initiation Factor 2 Signaling and Proteomic Changes in Primary Bovine Mammary Epithelial Cells
Sign Up to like & getrecommendations! Published in 2022 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb44030071
Abstract: We hypothesized that the general control nonderepressible 2 (GCN2)/eukaryotic initiation factor 2 (eIF2) signaling pathway and intracellular protein synthesis (PS) are regulated to maintain milk PS in primary bovine mammary epithelial cells (MECs) under essential… read more here.
Keywords: control nonderepressible; initiation factor; general control; control ... See more keywords
Effects of the eukaryotic initiation factor 6 gene on expression levels of inflammatory mediators in M2 macrophages during scar repair
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2017.7190
Abstract: Following the publication of this article, we regret to report that we have been unable to reproduce the results presented in the paper in our subsequent studies. At the present time, we have not been… read more here.
Keywords: medicine; eukaryotic initiation; initiation factor; gene expression ... See more keywords