Context-specific action of macrolide antibiotics on the eukaryotic ribosome
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DOI: 10.1038/s41467-021-23068-1
Abstract: Macrolide antibiotics bind in the nascent peptide exit tunnel of the bacterial ribosome and prevent polymerization of specific amino acid sequences, selectively inhibiting translation of a subset of proteins. Because preventing translation of individual proteins… read more here.
Keywords: specific action; translation; eukaryotic ribosome; macrolide antibiotics ... See more keywords
Crystal structure of eukaryotic ribosome and its complexes with inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2016.0184
Abstract: A high-resolution structure of the eukaryotic ribosome has been determined and has led to increased interest in studying protein biosynthesis and regulation of biosynthesis in cells. The functional complexes of the ribosome crystals obtained from… read more here.
Keywords: crystal structure; eukaryotic ribosome; structure eukaryotic; structure ... See more keywords
The Organizing Principles of Eukaryotic Ribosome Recruitment.
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DOI: 10.1146/annurev-biochem-013118-111042
Abstract: The stage at which ribosomes are recruited to messenger RNAs (mRNAs) is an elaborate and highly regulated phase of protein synthesis. Upon completion of this step, a ribosome is positioned at an appropriate initiation codon… read more here.
Keywords: biochemistry; ribosome recruitment; eukaryotic ribosome; principles eukaryotic ... See more keywords
Eukaryotic Ribosome Biogenesis: The 40S Subunit
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DOI: 10.32607/actanaturae.11540
Abstract: The formation of eukaryotic ribosomes is a sequential process of ribosomal precursors maturation in the nucleolus, nucleoplasm, and cytoplasm. Hundreds of ribosomal biogenesis factors ensure the accurate processing and formation of the ribosomal RNAs’ tertiary… read more here.
Keywords: ribosome assembly; eukaryotic ribosome; 40s subunit; ribosome biogenesis ... See more keywords
Eukaryotic Ribosome Biogenesis: The 60S Subunit
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DOI: 10.32607/actanaturae.11541
Abstract: Ribosome biogenesis is consecutive coordinated maturation of ribosomal precursors in the nucleolus, nucleoplasm, and cytoplasm. The formation of mature ribosomal subunits involves hundreds of ribosomal biogenesis factors that ensure ribosomal RNA processing, tertiary structure, and… read more here.
Keywords: eukaryotic ribosome; 60s subunit; subunit eukaryotic; ribosome biogenesis ... See more keywords
Shaping the Nascent Ribosome: AAA-ATPases in Eukaryotic Ribosome Biogenesis
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DOI: 10.3390/biom9110715
Abstract: AAA-ATPases are molecular engines evolutionarily optimized for the remodeling of proteins and macromolecular assemblies. Three AAA-ATPases are currently known to be involved in the remodeling of the eukaryotic ribosome, a megadalton range ribonucleoprotein complex responsible… read more here.
Keywords: aaa atpases; ribosome; eukaryotic ribosome; ribosome biogenesis ... See more keywords