Rational Design of a Replication-Competent and Inheritable Magnetic Viruses for Targeting Biomedical Applications.
Sign Up to like & getrecommendations! Published in 2020 at "Small"
DOI: 10.1002/smll.202002435
Abstract: Infection with live-attenuated vaccines always inevitably induces side effects that reduce their safety. This study suggests a concept of magnetic virus produced by genetically modifying viral surfaces with Fe3 O4 nanoparticles (NPs) to control their… read more here.
Keywords: ev71; rational design; ev71 fe3; replication competent ... See more keywords
Identification and production of mouse scFv to specific epitope of enterovirus-71 virion protein-2 (VP2)
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Virology"
DOI: 10.1007/s00705-018-3731-z
Abstract: Enterovirus-71 (EV71) and coxsackievirus-A16 (CA16) frequently cause hand-foot-mouth disease (HFMD) epidemics among infants and young children. CA16 infections are usually mild, while EV71 disease may be fatal due to neurologic complications. As such, the ability… read more here.
Keywords: ev71; protein vp2; protein; enterovirus ... See more keywords
Process optimization for the rapid production of Enterovirus 71
Sign Up to like & getrecommendations! Published in 2019 at "Cytotechnology"
DOI: 10.1007/s10616-019-00340-3
Abstract: Enterovirus 71 (EV71) infection can cause hand–foot-and-mouth disease (HFMD). Inactivated EV71 vaccine was effective to prevent EV71 derived HFMD. A highly efficient and economical process for producing EV71 is needed. In our study, the epidemic… read more here.
Keywords: ev71; production; enterovirus; optimization rapid ... See more keywords
Long non-coding RNA expression profiles in different severity EV71-infected hand foot and mouth disease patients
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and Biophysical Research Communications"
DOI: 10.1016/j.bbrc.2017.09.141
Abstract: Abstract Enterovirus 71 (EV71) is associated with the severe hand foot and mouth disease (HFMD) outcomes, however the host-virus interaction mechanism and the pathogenesis remain poorly understood. Long non-coding RNAs (lncRNAs) are involved in variety… read more here.
Keywords: ev71; foot mouth; expression; ev71 infected ... See more keywords
In Vitro and In Vivo Inhibition of the Infectivity of Human Enterovirus 71 by a Sulfonated Food Azo Dye, Brilliant Black BN
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Virology"
DOI: 10.1128/jvi.00061-19
Abstract: Human enterovirus 71 (EV71) is one of the causative agents of hand, foot, and mouth disease in children and is responsible for thousands of deaths in the past 20 years. Food azo dyes have been widely… read more here.
Keywords: food azo; food; enterovirus; ev71 ... See more keywords
Neddylation of Enterovirus 71 VP2 Protein Reduces Its Stability and Restricts Viral Replication
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00598-22
Abstract: Neddylation is a ubiquitin-like posttranslational modification by conjugation of neural precursor cell-expressed developmentally downregulated protein 8 (NEDD8) to specific proteins for regulation of their metabolism and biological activities. In this study, we demonstrated for the… read more here.
Keywords: ev71; vp2 protein; neddylation; replication ... See more keywords
Development of an Enterovirus 71 Vaccine Efficacy Test Using Human Scavenger Receptor B2 Transgenic Mice
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Virology"
DOI: 10.1128/jvi.01921-19
Abstract: The development of new vaccines for EV71 relies on the availability of small animal models suitable for in vivo efficacy testing. Monkeys and neonatal mice have been used, but the use of these animals has… read more here.
Keywords: mice; efficacy; development; efficacy test ... See more keywords
Neutralization Mechanisms of Two Highly Potent Antibodies against Human Enterovirus 71
Sign Up to like & getrecommendations! Published in 2018 at "mBio"
DOI: 10.1128/mbio.01013-18
Abstract: ABSTRACT Despite significant advances in health care, outbreaks of infections by enteroviruses (EVs) continue to plague the Asia-Pacific region every year. Enterovirus 71 (EV71) causes hand-foot-and-mouth disease (HFMD), for which there are currently no therapeutics.… read more here.
Keywords: highly potent; two antibodies; ev71; neutralizing antibodies ... See more keywords
Phosphorylation of ERK-Dependent NF-κB Triggers NLRP3 Inflammasome Mediated by Vimentin in EV71-Infected Glioblastoma Cells
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27134190
Abstract: Enterovirus 71 (EV71) is a dominant pathogenic agent that may cause severe central nervous system (CNS) diseases among infants and young children in the Asia-pacific. The inflammasome is closely implicated in EV71-induced CNS injuries through… read more here.
Keywords: glioblastoma cells; ev71; ev71 infected; vimentin ... See more keywords
A Single Mutation in the VP1 Gene of Enterovirus 71 Enhances Viral Binding to Heparan Sulfate and Impairs Viral Pathogenicity in Mice
Sign Up to like & getrecommendations! Published in 2020 at "Viruses"
DOI: 10.3390/v12080883
Abstract: Enterovirus 71 (EV71) is the major causative pathogen of human hand, foot, and mouth disease (hHFMD) and has evolved to use various cellular receptors for infection. However, the relationship between receptor preference and EV71 virulence… read more here.
Keywords: ev71; enterovirus; heparan sulfate; mutation vp1 ... See more keywords