A 5-FU Precursor Designed to Evade Anabolic and Catabolic Drug Pathways and Activated by Pd Chemistry In Vitro and In Vivo.
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DOI: 10.1021/acs.jmedchem.1c01733
Abstract: 5-Fluorouracil (5-FU) is an antineoplastic antimetabolite that is widely administered to cancer patients by bolus injection, especially to those suffering from colorectal and pancreatic cancer. Because of its suboptimal route of administration and dose-limiting toxicities,… read more here.
Keywords: evade anabolic; vivo; precursor designed; chemistry ... See more keywords