A phase 1 study to evaluate the safety, pharmacology, and feasibility of continuous infusion nelarabine in patients with relapsed and/or refractory lymphoid malignancies
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DOI: 10.1002/cncr.34570
Abstract: Nelarabine is a purine nucleoside analogue prodrug approved for the treatment of relapsed and refractory T‐cell acute lymphoblastic leukemia (R/R T‐ALL) and lymphoblastic lymphoma (T‐LBL). Although effective in R/R T‐ALL, significant neurotoxicity is dose‐limiting and… read more here.
Keywords: pharmacology; study evaluate; relapsed refractory; evaluate safety ... See more keywords
A Dose-Confirmation Phase 1 Study to Evaluate the Safety and Pharmacology of Glucarpidase in Healthy Volunteers.
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DOI: 10.1002/cpdd.1010
Abstract: Glucarpidase rapidly decomposes methotrexate. A phase 1 study of glucarpidase in an open-label, randomized parallel group was conducted to evaluate the safety, pharmacokinetics, and other pharmacologic effects in Japanese healthy volunteers without methotrexate treatment. A… read more here.
Keywords: glucarpidase; pharmacology; evaluate safety; phase study ... See more keywords
A phase 1 study to evaluate the safety, tolerability and pharmacokinetics of TAK‐041 in healthy participants and patients with stable schizophrenia
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DOI: 10.1111/bcp.15305
Abstract: TAK‐041 (NBI‐1065846), an orally available, investigational, small molecule agonist of GPR139, an orphan G‐protein‐coupled receptor, has shown promise in preclinical studies for the treatment of symptoms associated with schizophrenia. Here, we report the results from… read more here.
Keywords: study evaluate; evaluate safety; phase study; tolerability pharmacokinetics ... See more keywords
A clinical study to evaluate the safety and efficacy performance of the Morpheus8 applicator for the treatment of cellulite: A case series
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DOI: 10.1111/jocd.15283
Abstract: Cellulite is a significant cosmetic concern for postpubertal females and has been reported to affect 85% to 98% of postpubertal females across all races.1 The demand for treatment of cellulite has been on the rise… read more here.
Keywords: improvement; scale; safety efficacy; evaluate safety ... See more keywords
How do I: Evaluate the safety and legitimacy of unproven cellular therapies?
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DOI: 10.1111/trf.16814
Abstract: Unproven cellular therapies are being offered to patients for a variety of conditions and diseases for which other treatments have failed. The use of untested cellular therapies is a worldwide problem. Practitioners (e.g., physicians, scientists,… read more here.
Keywords: safety legitimacy; unproven cellular; cellular therapies; evaluate safety ... See more keywords
Single Ascending-Dose Study To Evaluate the Safety, Tolerability, and Pharmacokinetics of Sutezolid in Healthy Adult Subjects
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DOI: 10.1128/aac.02108-21
Abstract: The primary objective of the study was to evaluate the safety and tolerability of single oral doses of sutezolid tablets administered under fasting conditions in healthy adult subjects. The secondary objective was to determine the… read more here.
Keywords: study evaluate; evaluate safety; healthy adult; adult subjects ... See more keywords
A phase 2 study to evaluate the safety and efficacy of Intratumoral (IT) injection of the TLR9 agonist IMO-2125 (IMO) in combination with ipilimumab (ipi) in PD-1 inhibitor refractory melanoma.
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DOI: 10.1200/jco.2018.36.15_suppl.9515
Abstract: 9515Background: PD-1/L1 inhibitors have transformed MM treatment, however many patients (pts) remain refractory. Subsequent treatment options including ipi offer modest benefit (~13% respond) (Long... read more here.
Keywords: study evaluate; ipi; safety efficacy; evaluate safety ... See more keywords
An experimental study to evaluate safety/toxicity of intravitreal natalizumab
Sign Up to like & getrecommendations! Published in 2018 at "Indian Journal of Ophthalmology"
DOI: 10.4103/ijo.ijo_425_18
Abstract: Purpose: The purpose of this prospective experimental study was to evaluate the safety/toxicity of α4β1 integrin blockade in rabbit retina using its monoclonal antibody (Natalizumab). Methods: Twelve New Zealand albino rabbits were divided into three… read more here.
Keywords: safety toxicity; study evaluate; experimental study; group ... See more keywords