Enzymatic Cascade To Evaluate the Tricyclization of Glycopeptide Antibiotic Precursor Peptides as a Prequel to Biosynthetic Redesign.
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DOI: 10.1021/acs.orglett.9b03245
Abstract: Natural products are the greatest source of antimicrobial agents, although their structural complexity often renders synthetic production and diversification of key classes impractical. One pertinent example is the glycopeptide antibiotics (GPAs), which are highly challenging… read more here.
Keywords: evaluate tricyclization; precursor peptides; enzymatic cascade; cascade evaluate ... See more keywords