Evaluating the Advantages of Using 3D-Enriched Fragments for Targeting BET Bromodomains.
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DOI: 10.1021/acsmedchemlett.9b00414
Abstract: Fragment-based ligand discovery has been successful in targeting diverse proteins. Despite drug-like molecules having more 3D character, traditional fragment libraries are largely composed of flat, aromatic fragments. The use of 3D-enriched fragments for enhancing library… read more here.
Keywords: bet bromodomains; bet; advantages using; enriched fragments ... See more keywords