Design, Synthesis and Evaluation of AdSS Bisubstrate Inhibitors
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DOI: 10.1002/cmdc.202000498
Abstract: Many cancers lack the expression of methylthioadenosine phosphorylase (MTAP). These cancers require adenylosuccinate synthetase (AdSS) for nucleic acid synthesis. By inhibiting adenylosuccinate synthetase, we potentially have a new therapeutic agent. Bisubstrate inhibitors were synthesized and… read more here.
Keywords: evaluation adss; design synthesis; bisubstrate inhibitors; adss ... See more keywords