Evaluation of an antibody-PNA conjugate as a clearing agent for antibody-based PNA-mediated radionuclide pretargeting
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-77523-y
Abstract: Radionuclide molecular imaging of cancer-specific targets is a promising method to identify patients for targeted antibody therapy. Radiolabeled full-length antibodies however suffer from slow clearance, resulting in high background radiation. To overcome this problem, a… read more here.
Keywords: agent; antibody pna; radionuclide; antibody ... See more keywords
Assessing Computational Strategies for the Evaluation of Antibody Binding Affinities
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Chemical Theory and Computation"
DOI: 10.1101/2025.09.25.678535
Abstract: Accurate evaluation of binding affinity is critical in drug discovery to identify molecules that bind strongly to their targets while minimizing off-target effects. Although binding affinity calculations are theoretically well-defined, they require exhaustive sampling of… read more here.
Keywords: evaluation antibody; antibody; strategies evaluation; computational strategies ... See more keywords