Synthesis and Evaluation of the Antileishmanial Activity of Novel Eugenol Analogs Containing 1,2,3-Triazole Fragments Against Intracellular Leishmania braziliensis
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the Brazilian Chemical Society"
DOI: 10.21577/0103-5053.20230073
Abstract: This investigation describes the synthesis of eugenol analogs presenting 1,2,3-triazole fragments and evaluation of their antileishmanial activity. The alkylation of guaiacol (1) with allyl bromide afforded 1-(allyloxy)-2-methoxybenzene (2) (93% yield). The Claisen rearrangement conducted with… read more here.
Keywords: braziliensis; evaluation antileishmanial; triazole fragments; eugenol analogs ... See more keywords
Synthesis and Evaluation of Antileishmanial and Cytotoxic Activity of Benzothiopyrane Derivatives
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25040800
Abstract: In continuation of our efforts to identify promising antileishmanial agents based on the chroman scaffold, we synthesized several substituted 2H-thiochroman derivatives, including thiochromenes, thichromanones and hydrazones substituted in C-2 or C-3 with carbonyl or carboxyl… read more here.
Keywords: evaluation antileishmanial; antileishmanial cytotoxic; synthesis evaluation; activity benzothiopyrane ... See more keywords