Synthesis and characterization of furazan derivatives and their evaluation as antitumor agents
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DOI: 10.1007/s11696-019-00834-6
Abstract: In order to discover compounds with better biological activity, a series of furazan derivatives were synthesized based on the structural modification of INCB024360 (Epacadostat). The anti-proliferative activities of new synthesized compounds 4a–o were screened in… read more here.
Keywords: furazan derivatives; derivatives evaluation; characterization furazan; evaluation antitumor ... See more keywords
Evaluation of Antitumor Activity of Xanthones Conjugated with Amino Acids
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DOI: 10.3390/ijms25042121
Abstract: Cancer is a complex disease characterized by several alterations, which confer, to the cells, the capacity to proliferate uncontrollably and to resist cellular death. Multiresistance to conventional chemotherapy drugs is often the cause of treatment… read more here.
Keywords: cancer; evaluation antitumor; cell lines; antitumor activity ... See more keywords
Synthesis and the In Vitro Evaluation of Antitumor Activity of Novel Thiobenzanilides
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DOI: 10.3390/molecules28041877
Abstract: Cancer is a generic term for a large group of diseases that are the second-leading cause of death worldwide, accounting for nearly 10 million deaths in 2020. Melanoma is a highly aggressive skin tumor with… read more here.
Keywords: novel; synthesis vitro; breast cancer; vitro evaluation ... See more keywords