Synthesis and Evaluation of Bicyclic Hydroxypyridones as Inhibitors of Catechol O-Methyltransferase
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DOI: 10.1021/acsmedchemlett.9b00345
Abstract: A series of bicyclic pyridones were identified as potent inhibitors of catechol O-methyltransferase (COMT). Substituted benzyl groups attached to the basic nitrogen of the core scaffold gave the most potent inhibitors within this series. Rat… read more here.
Keywords: evaluation bicyclic; inhibitors catechol; catechol methyltransferase; bicyclic hydroxypyridones ... See more keywords