Thorough QT/QTc Evaluation of the Cardiac Safety of Secnidazole at Therapeutic and Supratherapeutic Doses in Healthy Individuals
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Pharmacology"
DOI: 10.1002/jcph.1014
Abstract: SYM‐1219, a novel oral granule formulation of secnidazole, is under development as single‐dose treatment for bacterial vaginosis. This 4‐way, randomized, crossover study evaluated the effects of SYM‐1219 on electrocardiographic (ECG) parameters in 52 healthy subjects.… read more here.
Keywords: sym 1219; qtc evaluation; safety; evaluation cardiac ... See more keywords
Evaluation of Cardiac Functions in Neonates with Hypoxic Ischemic Encephalopathy
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DOI: 10.1080/15513815.2025.2490029
Abstract: Abstract Introduction: The aim of our study was to evaluate the role of cardiac markers in determining prognosis in newborns with Perinatal Asphyxia (PA). Method: Patients with a pH mmol/L were defined as PA. NT-proBNP,… read more here.
Keywords: neonates hypoxic; evaluation cardiac; functions neonates; cardiac functions ... See more keywords
Comprehensive autophagy evaluation in cardiac disease models
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DOI: 10.1093/cvr/cvz233
Abstract: Abstract Autophagy is a highly conserved recycling mechanism essential for maintaining cellular homeostasis. The pathophysiological role of autophagy has been explored since its discovery 50 years ago, but interest in autophagy has grown exponentially over the… read more here.
Keywords: cardiac disease; comprehensive autophagy; evaluation cardiac; disease models ... See more keywords