Design, synthesis and evaluation of chalcones as H1N1 Neuraminidase inhibitors
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DOI: 10.1007/s00044-017-2124-2
Abstract: A series of chalcone derivatives (1a–2i) were designed based on isoliquiritigenin (the most active natural chalcone non-competitive neuraminidase (NA) inhibitor). Molecular modeling studies revealed that isoliquiritigenin and its designed analogs occupied 430-loop cavity of NA… read more here.
Keywords: h1n1 neuraminidase; design synthesis; chalcones h1n1; inhibition ... See more keywords
Design, synthesis, docking and biological evaluation of chalcones as promising antidiabetic agents.
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DOI: 10.1016/j.bioorg.2019.103527
Abstract: Diabetes mellitus (DM) is a serious chronic metabolic disorder which occurs due to dysfunction of insulin and therapeutic approaches are poor. It is an under estimation that 387 million people currently suffering globally with diabetic… read more here.
Keywords: design synthesis; synthesis docking; biological evaluation; evaluation chalcones ... See more keywords
Design, synthesis and biological evaluation of chalcones as reversers of P-glycoprotein-mediated multidrug resistance.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.05.053
Abstract: Overexpression of P-glycoprotein (P-gp) is one of the major causes for multidrug resistance (MDR), which has become a major obstacle in cancer therapy. One hopeful approach to reverse the MDR is to develop inhibitors of… read more here.
Keywords: synthesis biological; evaluation chalcones; multidrug resistance; biological evaluation ... See more keywords