Structure-based design, synthesis and evaluation of 2,4-diaminopyrimidine derivatives as novel caspase-1 inhibitors.
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DOI: 10.1016/j.bioorg.2018.03.019
Abstract: Interleukin-1β converting enzyme contributes in various inflammatory and autoimmune diseases by maturing pro-inflammatory cytokines IL-1β, IL-18 and IL-33. Therefore, inhibition caspase-1 may provide a potential therapeutic strategy for the treatment of chronic inflammatory diseases. Here… read more here.
Keywords: design synthesis; diaminopyrimidine derivatives; evaluation diaminopyrimidine; structure based ... See more keywords